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Literature summary for 3.4.22.1 extracted from

  • Mura, P.; Camalli, M.; Casini, A.; Gabbiani, C.; Messori, L.
    Trans-cis-cis-[RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2], (PMRu52), a novel ruthenium(II) compound acting as a strong inhibitor of cathepsin B (2010), J. Inorg. Biochem., 104, 111-117.
    View publication on PubMed
Search for more literature for 3.4.22.1

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol required to reduce the enzyme to its catalytically active form Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
trans-cis-cis-[RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2] i.e. (PMRu52), a ruthenium(II) compound acting as a strong inhibitor of cathepsin B, crystal structure and binding structure analysis, overview Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Bos taurus 5764
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Bos taurus
-
spleen
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-benzyloxycarbonyl-L-lysine 4-nitrophenyl ester + H2O
-
 Bos taurus N-benzyloxycarbonyl-L-lysine + 4-nitrophenol
-
 ?

Synonyms

Synonyms Comment Organism
cat B
-
 Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 assay at Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0055
-
 pH 6.0, 30°C Bos taurus trans-cis-cis-[RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2]