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Literature summary for 3.4.22.1 extracted from

  • Morishige, T.; Yoshioka, Y.; Tanabe, A.; Yao, X.; Tsunoda, S.; Tsutsumi, Y.; Mukai, Y.; Okada, N.; Nakagawa, S.
    Titanium dioxide induces different levels of IL-1beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B (2010), Biochem. Biophys. Res. Commun., 392, 160-165.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information phagocytosis of crystalline silica induces lysosomal destabilization and subsequent release of cathepsin B into the cytoplasm, leading to NALP3 activation. Release of specific proteases such as cathepsin B seems to be causally related to inflammasome activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CA-074-Me
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm phagocytosis of crystalline silica induces lysosomal destabilization and subsequent release of cathepsin B into the cytoplasm, leading to NALP3 activation Homo sapiens 5737
-
lysosome phagocytosis of crystalline silica induces lysosomal destabilization and subsequent release of cathepsin B into the cytoplasm, leading to NALP3 activation Homo sapiens 5764
-
additional information release of specific proteases such as cathepsin B seems to be causally related to inflammasome activation Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
THP-1 cell
-
 Homo sapiens
-

General Information

General Information Comment Organism
physiological function TiO2-induced interleukin-1beta production depends on active cathepsin B and reactive oxygen species production Homo sapiens