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Literature summary for 3.4.22.1 extracted from

  • Sun, B.; Zhou, Y.; Halabisky, B.; Lo, I.; Cho, S.H.; Mueller-Steiner, S.; Devidze, N.; Wang, X.; Grubb, A.; Gan, L.
    Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimers disease (2008), Neuron, 60, 247-257.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.1

Protein Variants

Protein Variants Comment Organism
additional information genetic ablation of CST3 in hAPP-J20 mice significantly lowers soluble amyloid beta levels, the relative abundance of amyloid beta 1-42, and plaque load. CysC removal also attenuates amyloid beta-associated cognitive deficits and behavioral abnormalities and restores synaptic plasticity in the hippocampus Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
cystatin C CysC or CST3, an endogenous inhibitor of cysteine proteases, including cathepsin B Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid beta peptide + H2O Mus musculus cathepsin B is involved in degradation of amyloid beta peptides, its inhibition can lead to amyloid beta accumulation, an early trigger of Alzheimer's disease, cystatin C regulates the enzyme negatively, CysC ablation ameliorates amyloid beta-associated neuronal and synaptic deficits in hippocampal circuits, neuroprotective effects of CysC ablation depend on CatB, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Mus musculus
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hippocampus
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid beta peptide + H2O
-
 Mus musculus ?
-
 ?
amyloid beta peptide + H2O cathepsin B is involved in degradation of amyloid beta peptides, its inhibition can lead to amyloid beta accumulation, an early trigger of Alzheimer's disease, cystatin C regulates the enzyme negatively, CysC ablation ameliorates amyloid beta-associated neuronal and synaptic deficits in hippocampal circuits, neuroprotective effects of CysC ablation depend on CatB, overview Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
CatB
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 Mus musculus