EC Number   |
Localization |
GeneOntology No. |
Reference |
|---|
   3.4.22.1 | apoplast |
- |
GO:0048046 AmiGO QuickGO |
682382 |
| 3.4.22.1 | caveola |
- |
GO:0005901 AmiGO QuickGO |
667869 |
| 3.4.22.1 | caveola |
of the lysosomal fraction, co-localization of active cathepsin B and its cell surface binding partners, S100A/p11 of the annexin II heterotetramer, to caveolae of human umbilical vein endothelial cells and colorectal carcinoma cells |
GO:0005901 AmiGO QuickGO |
697788 |
| 3.4.22.1 | cytoplasm |
- |
GO:0005737 AmiGO QuickGO |
753138 |
| 3.4.22.1 | cytoplasm |
in oxidative stress cathepsin B may be released from lysosomes into cytoplasm with lowered pH and cleave cytoplasmic proteins, including caspase-3 substrates |
GO:0005737 AmiGO QuickGO |
678362 |
| 3.4.22.1 | cytoplasm |
phagocytosis of crystalline silica induces lysosomal destabilization and subsequent release of cathepsin B into the cytoplasm, leading to NALP3 activation |
GO:0005737 AmiGO QuickGO |
707393 |
| 3.4.22.1 | cytosol |
- |
GO:0005829 AmiGO QuickGO |
681195, 753194 |
| 3.4.22.1 | endosome |
cathepsin B is synthesised as a pre-pro-enzyme and the primary pathways for its normal trafficking to the lysosome utilise mannose-6-phosphate receptors. Inactive pro-cathepsin-B is processed to active single and double chain forms of cathepsin-B in the late endosomes and lysosomes, respectively |
GO:0005768 AmiGO QuickGO |
698146 |
| 3.4.22.1 | exosome |
cathepsin B activity is detected in exosomes isolated from hydrogen peroxide treated cells |
- |
754239 |
| 3.4.22.1 | extracellular |
- |
- |
36621, 36631, 36649, 667869, 669599, 669985, 697710, 708747 |
