Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interleukin-6 | IL-6, in the presence of soluble form of IL-6 receptor, sIL-6R, enhances cathepsin B expression and activity via the Cav-1-JNK-AP-1 pathway in fibroblasts of the gingiva | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CA-074Me | a specific inhibitor for cathepsin B | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | regulation of cathepsin B in gingival fibroblasts involves interleukin-6 and its receptor along with the Cav-1-JNK-AP-1 pathway, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | gingival | Homo sapiens | - |
gingiva | - |
Homo sapiens | - |
additional information | JNK inhibition, but not p44/42 MAPK inhibition, significantly diminishes interleukin-6/soluble form of IL-6 receptor-induced cathepsin B production | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
carbobenzoxy-Phe-Ala-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | carbobenzoxy-Phe-Ala-Arg + 7-amino-4-methylcoumarin | - |
? | |
carbobenzoxy-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | carbobenzoxy-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
additional information | regulation of cathepsin B in gingival fibroblasts involves interleukin-6 and its receptor along with the Cav-1-JNK-AP-1 pathway, overview | Homo sapiens | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.2 | - |
assay at | Homo sapiens |