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Literature summary for 3.4.22.1 extracted from

  • Nagaraj, N.S.; Vigneswaran, N.; Zacharias, W.
    Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells (2006), J. Cancer Res. Clin. Oncol., 132, 171-183.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.1

Activating Compound

Activating Compound Comment Organism Structure
tumor necrosis factor-related apoptosis inducing ligand an increase in the cellular amount of active 31 kDa cathepsin B is observed after tumor necrosis factor-related apoptosis inducing ligand treatment (100 ng/ml) Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
L-trans-epoxysuccinyl-Ile-Pro-methyl ester complete inhibition at 0.025 mM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31000
-
 mature enzyme, SDS-PAGE Homo sapiens
43000
-
 proenzyme, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
oral squamous cell carcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-benzyloxycarbonyl-L-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-benzyloxycarbonyl-L-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?