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Literature summary for 3.4.22.1 extracted from

  • Duncan, J.A.; Gao, X.; Huang, M.T.; OConnor, B.P.; Thomas, C.E.; Willingham, S.B.; Bergstralh, D.T.; Jarvis, G.A.; Sparling, P.F.; Ting, J.P.
    Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome (2009), J. Immunol., 182, 6460-6469.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.1

Inhibitors

Inhibitors Comment Organism Structure
CA-074-Me i.e. [L-3-trans-(propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline methyl ester Homo sapiens
CA-074-Me i.e. [L-3-trans-(propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline methyl ester Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Mus musculus 5764
-
lysosome
-
 Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
-
monocyte
-
 Mus musculus
-
mononuclear cell peripheral blood Homo sapiens
-
THP-1 cell
-
 Homo sapiens
-
urethra
-
 Homo sapiens
-
uterine cervix
-
 Homo sapiens
-

General Information

General Information Comment Organism
physiological function in case of inflammation of the urethra and cervix after Neisseria gonorrhoeae infection, cathepsin B is an apical controlling step in the downstream activities of NLRP3 including interleukin-1beta production, pyronecrosis, and HMGB1 release. NLRP3 mediates cell death in B-lymphocytes and THP-1 cells Homo sapiens
physiological function infection with Neisseria gonorrhoeae induces cathepsin B in apical controlling of the downstream activities of NLRP3 including interleukin-1beta production, pyronecrosis, and HMGB1 release. NLRP3 mediates cell death in B-lymphocytes and macrophages, overview Mus musculus