Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | during in vivo liver fibrogenesis, caused by CCl4 administration, CtsB expression increases in hepatic stellate cells but not in hepatocytes | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | cathepsin B silencing by siRNA transfection decreases hepatic stellate cell proliferation and the expression of phenotypic markers of hepatic stellate cell activation, overview | Homo sapiens |
additional information | cathepsin B silencing or inhibition decreases hepatic stellate cell proliferation and the expression of phenotypic markers of hepatic stellate cell activation, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CA-074-Me | cathepsin B inhibition decreases hepatic stellate cell proliferation and the expression of phenotypic markers of hepatic stellate cell activation, and it down-regulate alpha-smooth musle actin mRNA and protein levels in LX2 cells, overview. Reduction of CtsB and/or CtsD levels by siRNA decreases cell proliferation, compared to control siRNA-transfected LX2 cells | Homo sapiens | |
CA-074-Me | a potent and specific CtsB inhibitor, CtsB inhibition blunts AKT phosphorylation in activated hepatic stellate cells in response to platelet-derived growth factor | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | secretion to the cell culture medium | Homo sapiens | - |
- |
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
C57BL/6 mice | - |
Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatic stellate cell | - |
Homo sapiens | - |
hepatic stellate cell | negligible expression of cathepsin B in hepatic stellate cells | Mus musculus | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
LX-2 cell | an immortalized hepatic stellate cell line | Homo sapiens | - |
additional information | during in vivo liver fibrogenesis, caused by CCl4 administration, CtsB expression increases in hepatic stellate cells but not in hepatocytes | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
CTSB | - |
Mus musculus |
CTSB | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | CtsB inhibition blunts AKT phosphorylation in activated hepatic stellate cells in response to platelet-derived growth factor. CtsB inactivation mitigates CCl4-induced inflammation, hepatic stellate cell activation, and collagen deposition | Mus musculus |
physiological function | cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential | Homo sapiens |
physiological function | cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential, the enzyme is required for transdifferentiation of the cells into myofibroblasts, overview. CtsB modulates the phosphoinositide 3-kinase/AKT pathway in activated mouse hepatic stellate cells, overview | Mus musculus |