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Literature summary for 3.4.22.1 extracted from

  • Moles, A.; Tarrats, N.; Fernandez-Checa, J.C.; Mari, M.
    Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential (2009), Hepatology, 49, 1297-1307.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information during in vivo liver fibrogenesis, caused by CCl4 administration, CtsB expression increases in hepatic stellate cells but not in hepatocytes Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information cathepsin B silencing by siRNA transfection decreases hepatic stellate cell proliferation and the expression of phenotypic markers of hepatic stellate cell activation, overview Homo sapiens
additional information cathepsin B silencing or inhibition decreases hepatic stellate cell proliferation and the expression of phenotypic markers of hepatic stellate cell activation, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
CA-074-Me cathepsin B inhibition decreases hepatic stellate cell proliferation and the expression of phenotypic markers of hepatic stellate cell activation, and it down-regulate alpha-smooth musle actin mRNA and protein levels in LX2 cells, overview. Reduction of CtsB and/or CtsD levels by siRNA decreases cell proliferation, compared to control siRNA-transfected LX2 cells Homo sapiens
CA-074-Me a potent and specific CtsB inhibitor, CtsB inhibition blunts AKT phosphorylation in activated hepatic stellate cells in response to platelet-derived growth factor Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secretion to the cell culture medium Homo sapiens
-
-
lysosome
-
Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
C57BL/6 mice
-
Mus musculus C57BL/6
-
C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatic stellate cell
-
Homo sapiens
-
hepatic stellate cell negligible expression of cathepsin B in hepatic stellate cells Mus musculus
-
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
LX-2 cell an immortalized hepatic stellate cell line Homo sapiens
-
additional information during in vivo liver fibrogenesis, caused by CCl4 administration, CtsB expression increases in hepatic stellate cells but not in hepatocytes Mus musculus
-

Synonyms

Synonyms Comment Organism
CTSB
-
Mus musculus
CTSB
-
Homo sapiens

General Information

General Information Comment Organism
malfunction CtsB inhibition blunts AKT phosphorylation in activated hepatic stellate cells in response to platelet-derived growth factor. CtsB inactivation mitigates CCl4-induced inflammation, hepatic stellate cell activation, and collagen deposition Mus musculus
physiological function cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential Homo sapiens
physiological function cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential, the enzyme is required for transdifferentiation of the cells into myofibroblasts, overview. CtsB modulates the phosphoinositide 3-kinase/AKT pathway in activated mouse hepatic stellate cells, overview Mus musculus