Literature summary for 3.4.22.1 extracted from

Zhang, F.T.; Zhang, Y.B.; Chen, Y.D.; Zhu, R.; Dong, C.W.; Li, Y.Y.; Zhang, Q.Y.; Gui, J.F.
Expressional induction of Paralichthys olivaceus cathepsin B gene in response to virus, poly I:C and lipopolysaccharide (2008), Fish Shellfish Immunol., 25, 542-549.

Search for more literature for 3.4.22.1

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	the enzyme expression is induced by virus, e.g. Scophthalmus maximus rhabdovirus, SMRV, or UV-inactivated grass carp hemorrhage virus, GCHV, by poly I:C, and lipopolysaccharide, overview. SMRV upregulation takes place predominantly in spleen, head kidney, posterior kidney, intestine, gill, and muscle	Paralichthys olivaceus

Cloned(Commentary)

Cloned (Comment)	Organism
gene PoCatB, cDNA is isolated from flounder embryonic cells treated with UV-inactivated grass carp hemorrhage virus, DNA and amino acid sequence determination and analysis	Paralichthys olivaceus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Paralichthys olivaceus	cathepsin B is a lysosomal cysteine protease of the papain-like enzyme family with multiple biological functions	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Paralichthys olivaceus	Q68J69	Japanese flounders, gene PoCatB	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	the enzyme contains a conserved glycosylation site	Paralichthys olivaceus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	cathepsin B is a lysosomal cysteine protease of the papain-like enzyme family with multiple biological functions	Paralichthys olivaceus	?	-	?

Subunits

Subunits	Comment	Organism
More	the enzyme contains an N-terminal signal peptide, cysteine protease active sites, the occluding loop segment and a glycosylation site, all of which are conserved in the cathepsin B family	Paralichthys olivaceus

Synonyms

Synonyms	Comment	Organism
CatB	-	Paralichthys olivaceus
More	cathepsin B is a lysosomal cysteine protease of the papain-like enzyme family	Paralichthys olivaceus

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Release 2023.1 (January 2023)