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Literature summary for 3.4.22.1 extracted from

  • Bhoopathi, P.; Chetty, C.; Gujrati, M.; Dinh, D.H.; Rao, J.S.; Lakka, S.
    Cathepsin B facilitates autophagy-mediated apoptosis in SPARC overexpressed primitive neuroectodermal tumor cells (2010), Cell Death Differ., 17, 1529-1539.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.1

Inhibitors

Inhibitors Comment Organism Structure
CA-074 Me a specific cathepsin B inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
D-283MED cell a medulloblastoma cell line Homo sapiens
-
DAOY cell a medulloblastoma cell line Homo sapiens
-
neuroectodermal tumor cell
-
 Homo sapiens
-
primitive neuroectodermal tumor cell
-
 Homo sapiens
-
SH-SY5Y cell a neuroblastoma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-Arg-Arg-4-methyl-7-amidocoumarin + H2O
-
 Homo sapiens Ac-Arg-Arg + 4-methyl-7-aminocoumarin
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens SPARC, i.e. secreted protein, acidic and rich in cysteine, a matrix-associated glycoprotein, expression induces autophagy, which results in the elevation of cathepsin B and subsequent mitochondria-mediated apoptosis up

General Information

General Information Comment Organism
malfunction specific blocking cathepsin B expression suppresses apoptosis but does not affect autophagy, which suggests that cathepsin B is a molecular link between autophagy and apoptosis. Cathepsin B inhibition decreases the SPARC-induced release of cytochrome c Homo sapiens
physiological function cathepsin B is a molecular link between autophagy and apoptosis. Cathepsin B mediates SPARC-induced apoptosis in primitive neuroectodermal tumor, PNET, cells, overview. SPARC is secreted protein, acidic and rich in cysteine, a matrix-associated glycoprotein. Cathepsin B inhibition decreases the SPARC-induced release of cytochorome c indicating that the release is due to cathepsin B activity Homo sapiens