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Literature summary for 3.4.22.1 extracted from

  • Czyzewska, J.; Guzinska-Ustymowicz, K.; Kemona, A.; Bandurski, R.
    The expression of matrix metalloproteinase 9 and cathepsin B in gastric carcinoma is associated with lymph node metastasis, but not with postoperative survival (2008), Folia Histochem. Cytobiol., 46, 57-64.
    View publication on PubMed
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Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
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 Homo sapiens 5764
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is involved in degradation of extracellular matrix and of basement membrane components leading to tumor invasion in the intestine. Expression of matrix metalloproteinase-9 and cathepsin B is correlated with lymph node metastasis in advanced gastric carcinoma, but not with patients' postoperative survival, overview. Correlation between the synthesis of cysteine and serine proteases and the potential tumor invasion ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
gastric cancer cell of a more aggressive tumor type, cathepsin B is most common in the intestinal type tumors infiltrating the whole gastric wall Homo sapiens
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intestine
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 Homo sapiens
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liver cancer cell higher levels of cathepsin B Homo sapiens
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lymphoma cell higher levels of cathepsin B Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in degradation of extracellular matrix and of basement membrane components leading to tumor invasion in the intestine. Expression of matrix metalloproteinase-9 and cathepsin B is correlated with lymph node metastasis in advanced gastric carcinoma, but not with patients' postoperative survival, overview. Correlation between the synthesis of cysteine and serine proteases and the potential tumor invasion Homo sapiens ?
-
 ?