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Literature summary for 3.4.22.1 extracted from

  • Colella, R.; Lu, G.; Glazewski, L.; Korant, B.; Matlapudi, A.; England, M.R.; Craft, C.; Frantz, C.N.; Mason, R.W.
    Induction of cell death in neuroblastoma by inhibition of cathepsins B and L (2010), Cancer Lett., 294, 195-203.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.1

Application

Application Comment Organism
medicine inhibition of cathepsins B and L may provide a unique mechanism for selectively inducing death of neuroblastoma with limited toxicity to normal cells and tissues Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Fmoc-Tyr-Ala-CHN2 FYAD, an irreversible inhibitor of cathepsin B, induces apoptosis of neuroblastoma cells but not of other tumor cells. Inhibitors that affect only one enzyme or fail to maintain inhibition of both cathepsins B and L do not induce apoptosis of these cells, overview Homo sapiens
additional information 95-100% enzyme inhibition is required to cause neuroblastoma cell death Homo sapiens
Z-Phe-Gly-NHO-Bz an inhibitor of both cathepsins B and L, causes death of many cell types Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
IMR-32 cell
-
 Homo sapiens
-
neuroblastoma cell
-
 Homo sapiens
-
SK-N-SH cell
-
 Homo sapiens
-

General Information

General Information Comment Organism
malfunction inhibition of cathepsin B impairs lysosomal proteolysis. FYAD, an irreversible inhibitor of cathepsin B, induces apoptosis of neuroblastoma cells but not of other tumor cells. Inhibition of cathepsin D does not rescue cells from FYAD-induced death Homo sapiens