Literature summary for 3.4.22.1 extracted from

Troy, A.M.; Sheahan, K.; Mulcahy, H.E.; Duffy, M.J.; Hyland, J.M.; ODonoghue, D.P.
Expression of cathepsin B and L antigen and activity is associated with early colorectal cancer progression (2004), Eur. J. Cancer, 40, 1610-1616.

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Inhibitors

Inhibitors	Comment	Organism	Structure
trans-epoxysuccinyl-L-leucyl-amido(4-guanidino)butane	E-64	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P07858	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colorectal cancer cell	-	Homo sapiens	-
colorectal mucosa	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O	1 mM DTT, 2 mM EDTA, pH 6.8, 37°C, activity varied from 0.013 to 3.4 U/mg protein in normal tissue and from 0.007 to 20.0 U/mg protein in cancer tissue	Homo sapiens	Z-Arg-Arg + 7-amino-4-methylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
cathepsin B	-	Homo sapiens

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Release 2023.1 (January 2023)