Literature summary for 3.4.22.1 extracted from

Lalanne, A.I.; Moraga, I.; Hao, Y.; Pereira, J.P.; Alves, N.L.; Huntington, N.D.; Freitas, A.A.; Cumano, A.; Vieira, P.
CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism (2010), J. Immunol., 184, 5678-5685.

Search for more literature for 3.4.22.1

Protein Variants

Protein Variants	Comment	Organism
additional information	the TLR9 ligand CpG DNA inhibits the proliferation of pro-B, but not pre-B, cells by inducing caspase-independent cell death through a pathway that requires the expression of cathepsin B in Rag-deficient mice carrying an SP6 transgene, in which B lymphopoiesis is compromised, to reduce the size of the B lymphocyte precursor compartments in the bone marrow, phenotype, overview	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Mus musculus	5764	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	wild-type C57BL/6 mice, and mutant B6 Rag2-/- and SP6 Rag2-/- Tg mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
B-lymphocyte	-	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	the TLR9 ligand CpG DNA inhibits the proliferation of pro-B, but not pre-B, cells by inducing caspase-independent cell death through a pathway that requires the expression of cathepsin B, mechanism, overview	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)