Literature summary for 3.4.22.1 extracted from

Watanabe, D.; Yamamoto, A.; Tomoo, K.; Matsumoto, K.; Murata, M.; Kitamura, K.; Ishida, T.
Quantitative evaluation of each catalytic subsite of cathepsin B for inhibitory activity based on inhibitory activity-binding mode relationship of epoxysuccinyl inhibitors by X-ray crystal structure analyses of complexes (2006), J. Mol. Biol., 362, 979-993.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapour diffusion method, in complex with inhibitors, in 50 mM citrate buffer (pH 3.5) containing 2.2-2.6 M sodium phosphate	Bos taurus

Inhibitors

Inhibitors	Comment	Organism	Structure
BzlNH-tES-Ile-Pro-OBzl	-	Bos taurus
BzlNH-tES-Ile-Pro-OH	-	Bos taurus
EtO-tES-Gly-Pro-OH	-	Bos taurus
EtO-tES-Ile-Ala-OH	-	Bos taurus
EtO-tES-Ile-Ile-OH	-	Bos taurus
EtO-tES-Ile-OH	-	Bos taurus
EtO-tES-Ile-Pro-OH	CA-030	Bos taurus
MeO-Gly-Gly-Leu-NH-tES-Leu-Pro-OH	NS-134	Bos taurus
N-(L-3-trans-carboxyoxirane-2-carbonyl)-L-leucylamino-3-methylbutane	E64c	Bos taurus
PrnNH-tES-Ile-Pro-OBzl	-	Bos taurus
PrnNH-tES-Ile-Pro-OH	CA-074	Bos taurus
PrnNH-tES-Ile-Pro-OMe	-	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Bos taurus	5764	-

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Bos taurus

Source Tissue

Source Tissue	Comment	Organism	Textmining
spleen	-	Bos taurus	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000023	-	-	Bos taurus	EtO-tES-Ile-Ala-OH
0.000024	-	-	Bos taurus	EtO-tES-Ile-Ile-OH
0.000029	-	-	Bos taurus	BzlNH-tES-Ile-Pro-OH
0.000038	-	-	Bos taurus	PrnNH-tES-Ile-Pro-OH
0.00004	-	-	Bos taurus	N-(L-3-trans-carboxyoxirane-2-carbonyl)-L-leucylamino-3-methylbutane
0.00012	-	-	Bos taurus	EtO-tES-Ile-Pro-OH
0.0091	-	-	Bos taurus	PrnNH-tES-Ile-Pro-OBzl
0.0153	-	-	Bos taurus	EtO-tES-Gly-Pro-OH
0.024	-	-	Bos taurus	EtO-tES-Ile-OH
0.046	-	-	Bos taurus	BzlNH-tES-Ile-Pro-OBzl
0.068	-	-	Bos taurus	PrnNH-tES-Ile-Pro-OMe

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Release 2023.1 (January 2023)