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Literature summary for 3.4.22.1 extracted from

  • Puissant, A.; Colosetti, P.; Robert, G.; Cassuto, J.P.; Raynaud, S.; Auberger, P.
    Cathepsin B release after imatinib-mediated lysosomal membrane permeabilization triggers BCR-ABL cleavage and elimination of chronic myelogenous leukemia cells (2010), Leukemia, 24, 115-124.
    View publication on PubMed
Search for more literature for 3.4.22.1

Activating Compound

Activating Compound Comment Organism Structure
imatinib activates cathepsin B and mediates its redistribution to the cytoplasm Homo sapiens
additional information pharmacological or short hairpin RNA-mediated inhibition of tyrosine kinase BCR-ABL triggers lysosomal membrane permeabilization that culminates in activation and redistribution of cathepsin B into the cytoplasm of chronic myelogenous leukemia cells, in which it triggers directly BCR-ABL degradation Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information knockdown of cathepsin B in K-562 cells by siRNA Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CA-074-Me
-
 Homo sapiens
additional information inhibition of cathepsin B increases cell viability in the presence of imatinib Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-
additional information imatinib mediates redistribution of cathepsin B, Iiatinib or BCR-ABL knockdown induces lysosomal membrane permeabilization that culminates in activation and redistribution of cathepsin B into the cytoplasm of chronic myelogenous leukemia cells Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant enzyme Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
leukemia cell chronic myelogenous Homo sapiens
-

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction cathepsin B confers protection against cell death in clonogenic assays of CD34+ primary cells from chronic myelogenous leukemia patients Homo sapiens
additional information cathepsin B release after imatinib-mediated lysosomal membrane permeabilization triggers tyrosine kinase BCR-ABL cleavage and elimination of chronic myelogenous leukemia cells, overview Homo sapiens