Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | bafilomycin A1 induces lysosome-associated podosome-like structures and promotes degradation of extracellular gelatin | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bafilomycin | - |
Mus musculus | |
E64c | - |
Mus musculus | |
E64d | - |
Mus musculus | |
N-(L-3-trans-propylcarbonyl-oxirane-2-carbonyl)-L-isoleucyl-L-proline | i.e. CA074, a cathepsin B-selective inhibitor | Mus musculus | |
N-(L-3-trans-propylcarbonyl-oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester | i.e. CA074Me, a cathepsin B-selective inhibitor | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | lysosomes localized at podosomes | Mus musculus | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | Mus musculus | - |
? | - |
? | |
additional information | Mus musculus | cathepsin B belongs to the lysosomal cysteine cathepsins, a third major class of matrix-degrading enzymes involved in tumor invasion and tissue remodeling. Cathepsin B is involved in matrix degradation at podosomes, cysteine protease inhibitors reduce matrix degradation and invasion in vitro | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | protease v-Src-transformed fibroblasts | Mus musculus | - |
NIH-3T3 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | - |
Mus musculus | ? | - |
? | |
additional information | cathepsin B belongs to the lysosomal cysteine cathepsins, a third major class of matrix-degrading enzymes involved in tumor invasion and tissue remodeling. Cathepsin B is involved in matrix degradation at podosomes, cysteine protease inhibitors reduce matrix degradation and invasion in vitro | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | cathepsin B belongs to the class of lysosomal cysteine cathepsins | Mus musculus |