Literature summary for 3.4.22.1 extracted from

Gunatilleke, S.S.; Barrios, A.M.
Tuning the Au(I)-mediated inhibition of cathepsin B through ligand substitutions (2008), J. Inorg. Biochem., 102, 555-563.

Search for more literature for 3.4.22.1

Inhibitors

Inhibitors	Comment	Organism	Structure
auranofin	competitive, reversible inhibitor of cathepsin B	Homo sapiens
chloro(triphenylphosphine)gold(I)	-	Homo sapiens
chloro(tris(p-fluorophenyl)phosphine)gold(I)	-	Homo sapiens
chloro[4-(diphenylphosphino-kappaP)benzenamine]gold(I)	-	Homo sapiens
chloro[4-(diphenylphosphino-kappaP)benzoato]gold(I)	-	Homo sapiens
chloro[diphenyl(phenylmethyl)phosphine]gold(I)	-	Homo sapiens
chloro[diphenyl[4-(2-phenyl-1,3-dioxolan-2-yl)phenyl]phosphine-kappaP]gold(I)	-	Homo sapiens
chloro[N-[2-(diphenylphosphino-kappaP)ethyl]benzamide]gold(I)	-	Homo sapiens
chloro[N-[2-(diphenylphosphino-kappaP)ethyl]benzeneacetamide]gold(I)	-	Homo sapiens
chloro[N-[2-(diphenylphosphino-kappaP)ethyl]benzenepropanamide]gold(I)	-	Homo sapiens
chloro[tris(p-methoxyphenyl)phosphine]gold(I)	-	Homo sapiens
chloro[tris(pentafluorophenyl)phosphine]gold(I)	-	Homo sapiens
chloro[[1,1'-biphenyl]-4-yldiphenylphosphine]gold(I)	-	Homo sapiens
sodium chloro[[4,4',4''-(phosphinidyne-kappaP)tris[benzenesulfonato]]aurate]	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-benzyloxycarbonyl-L-Arg-L-Arg-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	N-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000289	-	-	Homo sapiens	chloro[[1,1'-biphenyl]-4-yldiphenylphosphine]gold(I)
0.000334	-	-	Homo sapiens	chloro(triphenylphosphine)gold(I)
0.000765	-	-	Homo sapiens	chloro(tris(p-fluorophenyl)phosphine)gold(I)
0.0097	-	-	Homo sapiens	chloro[4-(diphenylphosphino-kappaP)benzoato]gold(I)
0.0097	-	-	Homo sapiens	chloro[tris(pentafluorophenyl)phosphine]gold(I)
0.064	-	-	Homo sapiens	chloro[diphenyl(phenylmethyl)phosphine]gold(I)
0.075	-	-	Homo sapiens	sodium chloro[[4,4',4''-(phosphinidyne-kappaP)tris[benzenesulfonato]]aurate]
0.078	-	-	Homo sapiens	chloro[tris(p-methoxyphenyl)phosphine]gold(I)
0.18	-	-	Homo sapiens	chloro[N-[2-(diphenylphosphino-kappaP)ethyl]benzamide]gold(I)
0.204	-	-	Homo sapiens	chloro[4-(diphenylphosphino-kappaP)benzenamine]gold(I)
0.23	-	-	Homo sapiens	chloro[diphenyl[4-(2-phenyl-1,3-dioxolan-2-yl)phenyl]phosphine-kappaP]gold(I)
0.28	-	-	Homo sapiens	chloro[N-[2-(diphenylphosphino-kappaP)ethyl]benzeneacetamide]gold(I)
0.35	-	-	Homo sapiens	chloro[N-[2-(diphenylphosphino-kappaP)ethyl]benzenepropanamide]gold(I)

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Release 2023.1 (January 2023)