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Literature summary for 3.4.22.1 extracted from

  • Spencer, J.; Rathnam, R.P.; Motukuri, M.; Kotha, A.K.; Richardson, S.C.; Hazrati, A.; Hartley, J.A.; Male, L.; Hursthouse, M.B.
    Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity (2009), Dalton Trans., 2009, 4299-4303.
    View publication on PubMed
Search for more literature for 3.4.22.1

Inhibitors

Inhibitors Comment Organism Structure
(acetatato-kO)[2-(1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-5-yl-kN4)phenyl-kC1](pyridine)palladium(1+)
-
 Mus musculus
(acetatato-kO)[2-(1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-5-yl-kN4)phenyl-kC1](triphenylphosphane)palladium(1+)
-
 Mus musculus
chloro[2-(1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-5-yl-kN4)phenyl-kC1](pyridine)palladium(1+)
-
 Mus musculus
chloro[2-(1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-5-yl-kN4)phenyl-kC1](triphenylphosphane)palladium(1+)
-
 Mus musculus
additional information growth inhibition of B-16 cells by the palladacycle compounds, overview Mus musculus
[(1-methyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one)PdCl]2
-
 Mus musculus
[2-(1-benzyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-5-yl-kN4)phenyl-kC1](chloro)(pyridine)palladium(1+)
-
 Mus musculus
[2-(1-benzyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-5-yl-kN4)phenyl-kC1](chloro)(triphenylphosphane)palladium(1+)
-
 Mus musculus
[Pd2(1-methyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one)2(m-1,2-ethanebis(diphenylphosphine))Cl2] structure analysis by NMR spectroscopy and in the solid state by X-ray crystallography; structure analysis by NMR spectroscopy and in the solid state by X-ray crystallography. It inhibits cathepsin B, and also K562 leukemia cells with an IC50 value of 0.0043 mM after 1 h exposure Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-16 cell a melanoma cell line Mus musculus
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 IC50 values for growth inhibition of K-562 cells by palladacycles, overview Mus musculus additional information
0.003
-
 pH not specified in the publication, temperature not specified in the publication Mus musculus [Pd2(1-methyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one)2(m-1,2-ethanebis(diphenylphosphine))Cl2]