EC Number   |
General Information |
Reference |
|---|
   3.4.22.1 | malfunction |
arsenite treatment of human glioblastoma cells induces autophagosome formation and permeabilization of mitochondria, followed by caspase 3/7-mediated apoptosis. Arsenite toxicity involves a complex interplay between autophagy and apoptosis in human glioblastoma cells and is associated with inhibition of CatB, mechanism, overview |
707625 |
| 3.4.22.1 | malfunction |
blocking CTSB expression using CTSB siRNA suppresses inflammatory response but does not affect apoptosis markedly |
734235 |
| 3.4.22.1 | malfunction |
BmCatB RNAi treatment results in an arrest of the larval-pupal transformation. RNAi-mediated BmCatB knockdown sustains the expression of BmCatD during the larval-pupal transformation. On the other hand, when BmCatD is inhibited via RNAi, the expression of BmCatB is upregulated |
708219 |
| 3.4.22.1 | malfunction |
both caspase 3 activation and PARP cleavage are significantly reduced in cells lacking cathepsin B. Mitochondrial membrane permeabilization as well as the release of cytochrome C and AIF from mitochondria into cytosol induced by doxorubicin are significantly diminished in cathepsin B suppressed cells. Cell viability following doxorubicin is significantly elevated in cells with cathepsin B silencing |
717228 |
| 3.4.22.1 | malfunction |
cathepsin B confers protection against cell death in clonogenic assays of CD34+ primary cells from chronic myelogenous leukemia patients |
709771 |
| 3.4.22.1 | malfunction |
cathepsin B is a major lysosomal protease, its overactivation is involved in muscular dystrophy, bone resorption, pulmonary emphysem, and tumor metastasis |
708258 |
| 3.4.22.1 | malfunction |
cathepsin B is involved in several cancers |
708275 |
| 3.4.22.1 | malfunction |
cathepsin B overexpression in glioblastoma is correlated with a short survival of the patient |
707002 |
| 3.4.22.1 | malfunction |
cathepsin B significantly decreases the number of apoptotic nuclei in both the cumulus cell layer of matured oocytes and blastocysts |
710021 |
| 3.4.22.1 | malfunction |
Cathepsin B silencing by RNAi in human colorectal cancer (CRC) cells inhibits their growth in soft agar, as well as their invasion capacity, tumoral expansion, and metastatic spread in immunodeficient mice |
734676 |
