Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1R,2S)-2-([(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino)cyclohexane-1-carboxylic acid | - |
Homo sapiens | |
(benzyl[(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino)acetonitrile | - |
Homo sapiens | |
([(8-hydroxy-5-nitroquinolin-7-yl)methyl](methyl)amino)acetonitrile | - |
Homo sapiens | |
([(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino)acetonitrile | best performing inhibitor is effective in cell-based in vitro models of tumor invasion, where it significantly abrogates invasion of MCF-10A neoT cells | Homo sapiens | |
1-(4-nitronaphthalen-1-yl)pyrrolidine | - |
Homo sapiens | |
2-bromo-4-nitronaphthalen-1-amine | - |
Homo sapiens | |
4-(4-nitronaphthalen-1-yl)morpholine | - |
Homo sapiens | |
4-nitronaphthalen-1-amine | - |
Homo sapiens | |
4-nitronaphthalen-1-ol | - |
Homo sapiens | |
5,7-dinitroquinolin-8-ol | - |
Homo sapiens | |
5-nitro-7-((4-[(pyridin-3-yl)methyl]piperazin-1-yl)methyl)quinolin-8-ol | - |
Homo sapiens | |
5-nitro-7-((4-[(pyridin-4-yl)methyl]piperazin-1-yl)methyl)quinolin-8-ol | - |
Homo sapiens | |
5-nitro-N-[(pyridin-2-yl)methyl]quinolin-8-amine | - |
Homo sapiens | |
7-([(2R)-2-methylpiperidin-1-yl]methyl)-5-nitroquinolin-8-ol | - |
Homo sapiens | |
7-[(benzylamino)methyl]-5-nitroquinolin-8-ol | - |
Homo sapiens | |
7-[(ethylamino)methyl]-5-nitroquinolin-8-ol | - |
Homo sapiens | |
8-(4-methylpiperidin-1-yl)-5-nitroquinoline | - |
Homo sapiens | |
8-(morpholin-4-yl)-5-nitroquinoline | - |
Homo sapiens | |
8-hydroxy-5-nitroquinoline-7-carboxylic acid | - |
Homo sapiens | |
ethyl (1R,2S)-2-([(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino)cyclohexane-1-carboxylate | - |
Homo sapiens | |
ethyl 1-(5-nitroquinolin-8-yl)piperidine-4-carboxylate | - |
Homo sapiens | |
ethyl 4-[(8-hydroxy-5-nitroquinolin-7-yl)methyl]piperazine-1-carboxylate | - |
Homo sapiens | |
N,N-dimethyl-1-(5-nitroquinolin-8-yl)piperidine-3-carboxamide | - |
Homo sapiens | |
N-benzyl-5-nitroquinolin-8-amine | - |
Homo sapiens | |
N-benzyl-N-methyl-5-nitroquinolin-8-amine | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH + H2O | exopeptidase activity | Homo sapiens | ? | - |
? | |
CBZ-Arg-Arg-7-amido-4-methylcoumarin + H2O | endopeptidase activity | Homo sapiens | CBZ-Arg-Arg + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cathepsin B | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5 | - |
assay at, endopeptidase activity | Homo sapiens |
6 | - |
assay at, exopeptidase activity | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.005 | - |
([(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino)acetonitrile | Ki-value (dissociation of the enzyme-substrate-inhibitor-complex), substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.019 | - |
(benzyl[(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino)acetonitrile | Ki-value (dissociation of the enzyme-substrate-inhibitor-complex), substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.024 | - |
8-(4-methylpiperidin-1-yl)-5-nitroquinoline | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.032 | - |
2-bromo-4-nitronaphthalen-1-amine | Ki-value (dissociation of the enzyme-substrate-inhibitor-complex), substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.034 | - |
1-(4-nitronaphthalen-1-yl)pyrrolidine | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.038 | - |
ethyl 1-(5-nitroquinolin-8-yl)piperidine-4-carboxylate | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.047 | - |
5-nitro-N-[(pyridin-2-yl)methyl]quinolin-8-amine | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.072 | - |
5,7-dinitroquinolin-8-ol | Ki-value (dissociation of the enzyme-substrate-inhibitor-complex), substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.079 | - |
(benzyl[(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino)acetonitrile | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.085 | - |
4-(4-nitronaphthalen-1-yl)morpholine | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.105 | - |
N,N-dimethyl-1-(5-nitroquinolin-8-yl)piperidine-3-carboxamide | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.107 | - |
5-nitro-N-[(pyridin-2-yl)methyl]quinolin-8-amine | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.117 | - |
8-hydroxy-5-nitroquinoline-7-carboxylic acid | Ki-value (dissociation of the enzyme-substrate-inhibitor-complex), substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.117 | - |
7-[(ethylamino)methyl]-5-nitroquinolin-8-ol | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.126 | - |
([(8-hydroxy-5-nitroquinolin-7-yl)methyl](methyl)amino)acetonitrile | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.129 | - |
ethyl 4-[(8-hydroxy-5-nitroquinolin-7-yl)methyl]piperazine-1-carboxylate | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.13 | - |
ethyl (1R,2S)-2-([(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino)cyclohexane-1-carboxylate | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.132 | - |
ethyl (1R,2S)-2-([(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino)cyclohexane-1-carboxylate | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.136 | - |
7-[(ethylamino)methyl]-5-nitroquinolin-8-ol | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.143 | - |
5-nitro-7-((4-[(pyridin-4-yl)methyl]piperazin-1-yl)methyl)quinolin-8-ol | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.146 | - |
5,7-dinitroquinolin-8-ol | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.147 | - |
4-nitronaphthalen-1-amine | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.154 | - |
7-[(benzylamino)methyl]-5-nitroquinolin-8-ol | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.155 | - |
8-(morpholin-4-yl)-5-nitroquinoline | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.155 | - |
N,N-dimethyl-1-(5-nitroquinolin-8-yl)piperidine-3-carboxamide | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.156 | - |
ethyl 4-[(8-hydroxy-5-nitroquinolin-7-yl)methyl]piperazine-1-carboxylate | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.162 | - |
5-nitro-7-((4-[(pyridin-4-yl)methyl]piperazin-1-yl)methyl)quinolin-8-ol | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.162 | - |
ethyl 1-(5-nitroquinolin-8-yl)piperidine-4-carboxylate | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.17 | - |
1-(4-nitronaphthalen-1-yl)pyrrolidine | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.172 | - |
([(8-hydroxy-5-nitroquinolin-7-yl)methyl](methyl)amino)acetonitrile | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.18 | - |
8-(morpholin-4-yl)-5-nitroquinoline | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.181 | - |
(1R,2S)-2-([(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino)cyclohexane-1-carboxylic acid | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.196 | - |
N-benzyl-N-methyl-5-nitroquinolin-8-amine | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.198 | - |
7-[(benzylamino)methyl]-5-nitroquinolin-8-ol | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.203 | - |
7-([(2R)-2-methylpiperidin-1-yl]methyl)-5-nitroquinolin-8-ol | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.207 | - |
8-(4-methylpiperidin-1-yl)-5-nitroquinoline | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.212 | - |
2-bromo-4-nitronaphthalen-1-amine | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.217 | - |
4-nitronaphthalen-1-amine | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.221 | - |
8-hydroxy-5-nitroquinoline-7-carboxylic acid | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.242 | - |
N-benzyl-N-methyl-5-nitroquinolin-8-amine | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.243 | - |
7-([(2R)-2-methylpiperidin-1-yl]methyl)-5-nitroquinolin-8-ol | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.25 | - |
(1R,2S)-2-([(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino)cyclohexane-1-carboxylic acid | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.289 | - |
4-(4-nitronaphthalen-1-yl)morpholine | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.311 | - |
5-nitro-7-((4-[(pyridin-3-yl)methyl]piperazin-1-yl)methyl)quinolin-8-ol | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.349 | - |
N-benzyl-5-nitroquinolin-8-amine | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.364 | - |
5-nitro-7-((4-[(pyridin-3-yl)methyl]piperazin-1-yl)methyl)quinolin-8-ol | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.364 | - |
N-benzyl-5-nitroquinolin-8-amine | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens | |
0.373 | - |
4-nitronaphthalen-1-ol | substrate: CBZ-Arg-Arg-4-methyl-7-coumarylamide (endopeptidase inhibition), pH 5, 37°C | Homo sapiens | |
0.426 | - |
([(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino)acetonitrile | substrate: 2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH (exopeptidase inhibition), pH 6, 37°C | Homo sapiens |