Literature summary for 3.4.22.1 extracted from

Hasnain, S.; Hirama, T.; Huber, C.P.; Mason, P.; Mort, J.S.
Characterization of cathepsin B specificity by site-directed mutagenesis. Importance of Glu245 in the S2-P2 specificity for arginine and its role in transition state stabilization (1993), J. Biol. Chem., 268, 235-240.

Search for more literature for 3.4.22.1

Protein Variants

Protein Variants	Comment	Organism
E245A	reduced Kcat for benzyloxycarbonyl-Arg-Arg-p-nitroanilide	Rattus norvegicus
E245Q	reduced Kcat for benzyloxycarbonyl-Phe-Arg-p-nitroanilide and benzyloxycarbonyl-Arg-Arg-p-nitroanilide	Rattus norvegicus
R202A	no significant effect on kinetic contstants with benzyloxycarbonyl-Phe-Arg-p-nitroanilide or benzyloxycarbonyl-Arg-Arg-p-nitroanilide	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Proteins + H2O	Rattus norvegicus	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Proteins + H2O	-	Rattus norvegicus	?	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)