Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CA-074 | cathepsin B inhibitor III, i.e. [L-3-trans-(propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline | Homo sapiens | |
CA-074Me | cathepsin B specific inhibitor, cathepsin B inhibitor IV, i.e. [L-3-trans-(propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline methyl ester | Homo sapiens | |
E-64d | i.e. (L-3-trans-ethoxycarbonyloxirane-2-carbonyl)-L-leucine(3-methylbutyl)amide | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
H4 neuroglioma cell | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
neuroglioma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein C-terminal fragment + H2O | cathepsin B degraded C-terminal fragments regardless of phosphorylation | Homo sapiens | ? | - |
? | |
amyloid precursor protein intracellular domain + H2O | - |
Homo sapiens | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of cathepsin B has no inhibitory effect on Notch processing | Homo sapiens |
physiological function | cathepsin B plays a role in the metabolism of amyloid precursor protein. Cathepsin B is a major CTF- and AICD-degrading enzyme with no effect on alpha- and beta-secretase activities | Homo sapiens |