Literature summary for 3.4.22.B70 extracted from

Xia, W.; Tian, H.; Cai, X.; Kong, H.; Fu, W.; Xing, W.; Wang, Y.; Zou, M.; Hu, Y.; Xu, D.
Inhibition of SUMO-specific protease 1 induces apoptosis of astroglioma cells by regulating NF-kappaB/Akt pathways (2016), Gene, 595, 175-179 .

Search for more literature for 3.4.22.B70

Application

Application	Comment	Organism
medicine	the expression of SENP1 is positively correlated with the malignant grades of astrocytoma. The NF-kappaB and Akt signaling pathways in glioblastoma multiforme tissues are activated. Knock-down of endogenous SENP1 promotes cell apoptosis. Downregulation of SENP1 expression can inhibit the phosphorylation of IkappaBalpha and Akt, and also the expression of its downstream regulation factors Bcl-xL and cyclinD1	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9P0U3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-
glioma cell	-	Homo sapiens	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)