Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4,4'-diisothiocyanatostilbene-2,2' disulfonic acid | P2-purinoceptor antagonist, less potent inhibition, IC50: 0.022 mM | Rattus sp. | |
5'-phosphoadenosine 3'-phosphate | P2-purinoceptor antagonist, less potent inhibitor, IC50: 0.036 mM | Rattus sp. | |
pyridoxal phosphate-6-azophenyl-2',4'disulfonic acid | P2-purinoceptor antagonist, potent inhibitor, IC50: 0.012 mM | Rattus sp. | |
Reactive blue 2 | P2-purinoceptor antagonist, potent inhibitor, IC50: 0.012 mM | Rattus sp. | |
suramin | P2-purinoceptor antagonist, less potent inhibitor, IC50: 0.072 mM | Rattus sp. |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Rattus sp. | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | Rattus sp. | extracellular ATP mainly hydrolysed by ecto-nucleotide pyrophosphatase, enzyme modulates purinoceptor-mediated signal transduction | AMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus sp. | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioma cell | - |
Rattus sp. | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | extracellular ATP mainly hydrolysed by ecto-nucleotide pyrophosphatase, enzyme modulates purinoceptor-mediated signal transduction | Rattus sp. | AMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ecto-nucleotide pyrophosphatase | - |
Rattus sp. |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.012 | - |
P2-purinoceptor antagonist, potent inhibitor, IC50: 0.012 mM | Rattus sp. | Reactive blue 2 | |
0.012 | - |
P2-purinoceptor antagonist, potent inhibitor, IC50: 0.012 mM | Rattus sp. | pyridoxal phosphate-6-azophenyl-2',4'disulfonic acid | |
0.022 | - |
P2-purinoceptor antagonist, less potent inhibition, IC50: 0.022 mM | Rattus sp. | 4,4'-diisothiocyanatostilbene-2,2' disulfonic acid | |
0.036 | - |
P2-purinoceptor antagonist, less potent inhibitor, IC50: 0.036 mM | Rattus sp. | 5'-phosphoadenosine 3'-phosphate | |
0.072 | - |
P2-purinoceptor antagonist, less potent inhibitor, IC50: 0.072 mM | Rattus sp. | suramin |