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Literature summary for 3.1.4.4 extracted from
- Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-kappaB/Sp1-mediated signaling pathways (2009), Carcinogenesis, 30, 356-365.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| phorbol 12-myristate 13-acetate | a protein kinase C activator also activates PLD, activation is inhibited by 1-butanol | Homo sapiens |  |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K758R | catalytically inactive mutant of isozyme PLD2 | Homo sapiens |
| K898R | catalytically inactive mutant of isozyme PLD1 | Homo sapiens |
| additional information | overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-kappaB/Sp1-mediated signaling pathways | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-butanol | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | NF-kappaB and transcription factor Sp1 are essential transcriptional factors linking PLD to MMP-2 upregulation | ? | - |
? | |
| phosphatidylcholine + H2O | Homo sapiens | - |
choline + phosphatidic acid | phosphatidic acid induces upregulation of MMP-2 mediated by protein kinase C, protein kinase A, nuclear factor-kappaB, and Sp1. Phosphatidic acid induces nuclear localization and the transactivation of NF-kappaB in glioma cells. | ? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isozymes PLD1 and PLD2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-172 cell | a glioma cell line | Homo sapiens | - |
| astrocyte | - |
Homo sapiens | - |
| glioma cell | - |
Homo sapiens | - |
| additional information | phospholipase D isozymes are overexpressed in various human tumor tissues and involved in tumorigenesis | Homo sapiens | - |
| T-98G cell | a glioma cell line | Homo sapiens | - |
| U-373MG cell | a glioma cell line | Homo sapiens | - |
| U-87MG cell | a glioma cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | NF-kappaB and transcription factor Sp1 are essential transcriptional factors linking PLD to MMP-2 upregulation | Homo sapiens | ? | - |
? | |
| phosphatidylcholine + H2O | - |
Homo sapiens | choline + phosphatidic acid | - |
? | |
| phosphatidylcholine + H2O | - |
Homo sapiens | choline + phosphatidic acid | phosphatidic acid induces upregulation of MMP-2 mediated by protein kinase C, protein kinase A, nuclear factor-kappaB, and Sp1. Phosphatidic acid induces nuclear localization and the transactivation of NF-kappaB in glioma cells. | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PLD | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | phospholipase D isozymes are overexpressed in various human tumor tissues and involved in tumorigenesis. The increased expression of PLD and its enzymatic activity in the glioma stimulate the secretion and expression of matrix metalloproteinase 2, MMP-2 and induce the invasiveness of glioma cells, mechanism, overview | Homo sapiens |
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