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Literature summary for 1.1.1.42 extracted from

  • Lopez, G.Y.; Reitman, Z.J.; Solomon, D.; Waldman, T.; Bigner, D.D.; McLendon, R.E.; Rosenberg, S.A.; Samuels, Y.; Yan, H.
    IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain (2010), Biochem. Biophys. Res. Commun., 398, 585-587.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.42

Protein Variants

Protein Variants Comment Organism
R132C naturally occuring mutation of IDH1 in melanoma metastasis of the lung Homo sapiens
R132X naturally occuring mutation of IDH1 in metastatic brain tumors Homo sapiens
R172X naturally occuring mutations of IDH2 in metastatic brain tumors Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NADP+ Homo sapiens
-
 2-oxoglutarate + NADPH + H+ + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O75874 IDH1
-
Homo sapiens P48735 IDH2
-

Source Tissue

Source Tissue Comment Organism Textmining
glioma cell progressive gliomas Homo sapiens
-
melanoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NADP+
-
 Homo sapiens 2-oxoglutarate + NADPH + H+ + CO2
-
 ?

Synonyms

Synonyms Comment Organism
IDH1
-
 Homo sapiens
IDH2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function elective pressures in the brain environment may specifically favor the cell growth or survival of tumor cells with mutations in IDH1, regardless of primary tumor site Homo sapiens
physiological function elective pressures in the brain environment may specifically favor the cell growth or survival of tumor cells with mutations in IDH2, regardless of primary tumor site Homo sapiens