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Information on EC - [heparan sulfate]-glucosamine 3-sulfotransferase 1

for references in articles please use BRENDA:EC2.8.2.23
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This enzyme differs from the other [heparan sulfate]-glucosamine 3-sulfotransferases [EC ([heparan sulfate]-glucosamine 3-sulfotransferase 2) and EC ([heparan sulfate]-glucosamine 3-sulfotransferase 3)] by being the most selective for a precursor of the antithrombin-binding site. It has a minimal acceptor sequence of: -> GlcNAc6S-> GlcA-> GlcN2S*+/-6S-> IdoA2S-> GlcN2S-> , the asterisk marking the target (symbols as in {iupac/2carb/38::2-Carb-38}) using +/- to mean the presence or absence of a substituent, and > to separate a predominant structure from a minor one. Thus Glc(N2S > NAc) means a residue of glucosamine where the N carries a sulfo group mainly but occasionally an acetyl group.) [1-4]. It can also modify other precursor sequences within heparan sulfate but this action does not create functional antithrombin-binding sites. These precursors are variants of the consensus sequence: -> Glc(N2S > NAc)+/-6S-> GlcA-> GlcN2S*+/-6S-> GlcA > IdoA+/-2S-> Glc(N2S/NAc)+/-6S-> . If the heparan sulfate substrate lacks 2-O-sulfation of GlcA residues, then enzyme specificity is expanded to modify selected glucosamine residues preceded by IdoA as well as GlcA .
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  • checkpoint
  • immunotherapy
  • nsclc
  • non-small
  • death-ligand
  • tumor-infiltrating
  • anti-pd-l1
  • death-1
  • ligand-1
  • evasion
  • pembrolizumab
  • worse
  • pd-l1-positive
  • paraffin-embedded
  • non-small-cell
  • durable
  • tumor-associated
  • nivolumab
  • progression-free
  • ctla-4
  • intratumoral
  • tregs
  • formalin-fixed
  • pathologist
  • urothelial
  • immunotherapeutic
  • anti-programmed
  • atezolizumab
  • immune-checkpoint
  • ventana
  • neoadjuvant
  • recurrence-free
  • foxp3+
  • co-stimulatory
  • 3-o-sulfation
  • co-inhibitory
  • durvalumab
  • h-scores
  • egfr-tkis
  • sarcomatoid
  • ido
  • avelumab
  • medicine
  • egfr-mutant
  • analysis
  • cd8-positive
The enzyme appears in viruses and cellular organisms
3-ost-1, hs3st1, 3-ost-4, 3-o-sulfotransferase-1, heparan sulfate d-glucosaminyl 3-o-sulfotransferase, 3-ost1, heparan sulfate 3-o-sulfotransferase-1, heparan sulfate 3-o-sulfotransferase 1, hs3st-2, 3ost1, more
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
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This enzyme differs from the other [heparan sulfate]-glucosamine 3-sulfotransferases, EC [heparan sulfate]-glucosamine 3-sulfotransferase 2 and EC [heparan sulfate]-glucosamine 3-sulfotransferase 3 by being the most selective for a precursor of the antithrombin-binding site
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