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Information on EC 2.8.2.23 - [heparan sulfate]-glucosamine 3-sulfotransferase 1

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IUBMB Comments
This enzyme differs from the other [heparan sulfate]-glucosamine 3-sulfotransferases [EC 2.8.2.29 ([heparan sulfate]-glucosamine 3-sulfotransferase 2) and EC 2.8.2.30 ([heparan sulfate]-glucosamine 3-sulfotransferase 3)] by being the most selective for a precursor of the antithrombin-binding site. It has a minimal acceptor sequence of: -> GlcNAc6S-> GlcA-> GlcN2S*+/-6S-> IdoA2S-> GlcN2S-> , the asterisk marking the target (symbols as in {iupac/2carb/38::2-Carb-38}) using +/- to mean the presence or absence of a substituent, and > to separate a predominant structure from a minor one. Thus Glc(N2S > NAc) means a residue of glucosamine where the N carries a sulfo group mainly but occasionally an acetyl group. [1-4]. It can also modify other precursor sequences within heparan sulfate but this action does not create functional antithrombin-binding sites. These precursors are variants of the consensus sequence: -> Glc(N2S > NAc)+/-6S-> GlcA-> GlcN2S*+/-6S-> GlcA > IdoA+/-2S-> Glc(N2S/NAc)+/-6S-> . If the heparan sulfate substrate lacks 2-O-sulfation of GlcA residues, then enzyme specificity is expanded to modify selected glucosamine residues preceded by IdoA as well as GlcA .
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The enzyme appears in viruses and cellular organisms
Synonyms
3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase, 3-O-sulfotransferase-1, 3-O-sulfotransferases-1, 3-OST-1, 3-OST-4, 3-OST1, 3OST1, gD-type 3-O-sulfotransferase-4, gD-type-3-OST-1, gD-type-3-OST-4, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
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This enzyme differs from the other [heparan sulfate]-glucosamine 3-sulfotransferases, EC 2.8.2.29: [heparan sulfate]-glucosamine 3-sulfotransferase 2 and EC 2.8.2.30: [heparan sulfate]-glucosamine 3-sulfotransferase 3 by being the most selective for a precursor of the antithrombin-binding site
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