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Enzyme Nomenclature
Information on EC 1.14.14.14 - aromatase
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1.14.14.14 aromataseIUBMB Comments
A cytochrome P-450. The enzyme catalyses three sequential hydroxylations of the androgens androst-4-ene-3,17-dione and testosterone, resulting in their aromatization and forming the estrogens estrone and 17beta-estradiol, respectively. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.
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Word Map
- 1.14.14.14
- estrogen
- breast
- women
- steroid
- androgen
-
postmenopausal
- tamoxifen
- ovarian
-
adjuvant
- progesterone
- letrozole
- ovary
- follicle
- gonad
-
granulosa
- anastrozole
-
steroidogenic
- fsh
-
receptor-positive
- exemestane
- androstenedione
- steroidogenesis
- lutein
- endometrial
- gonadotropin
- follicular
- testicular
-
hormone-dependent
-
er-positive
-
preoptic
-
follicle-stimulating
-
neoadjuvant
-
third-generation
-
estrogen-dependent
- oestradiol
- gnrh
- dihydrotestosterone
-
nonsteroidal
- endometriosis
-
premenopausal
-
antiestrogens
-
fulvestrant
- medicine
- arthralgia
-
her2-negative
-
17beta-hydroxysteroid
- progestin
-
upfront
- raloxifene
-
5alpha-reductase
- cyp17a1
The enzyme appears in viruses and cellular organisms
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REACTION 
REACTION DIAGRAM
COMMENTARY 
ORGANISM
UNIPROT
LITERATURE
19-hydroxyandrost-4-ene-3,17-dione + O2 + [reduced NADPH-hemoprotein reductase] = 19-oxo-androst-4-ene-3,17-dione + 2 H2O + [oxidized NADPH-hemoprotein reductase]
(2b)
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-
19-hydroxytestosterone + O2 + [reduced NADPH-hemoprotein reductase] = 19-oxotestosterone + 2 H2O + [oxidized NADPH-hemoprotein reductase]
(1b)
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-
19-oxoandrost-4-ene-3,17-dione + O2 + [reduced NADPH-hemoprotein reductase] = estrone + formate + H2O + [oxidized NADPH-hemoprotein reductase]
catalytic reaction mechanism, detailed overview
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-
19-oxotestosterone + O2 + [reduced NADPH-hemoprotein reductase] = 17beta-estradiol + formate + H2O + [oxidized NADPH-hemoprotein reductase]
(1c)
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-
androst-4-ene-3,17-dione + 3 O2 + 3 [reduced NADPH-hemoprotein reductase] = estrone + formate + 4 H2O + 3 [oxidized NADPH-hemoprotein reductase]
(2)
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-
androst-4-ene-3,17-dione + O2 + [reduced NADPH-hemoprotein reductase] = 19-hydroxyandrost-4-ene-3,17-dione + H2O + [oxidized NADPH-hemoprotein reductase]
(2a)
-
-
testosterone + 3 O2 + 3 [reduced NADPH-hemoprotein reductase] = 17beta-estradiol + formate + 4 H2O + 3 [oxidized NADPH-hemoprotein reductase]
(1)
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-
testosterone + O2 + [reduced NADPH-hemoprotein reductase] = 19-hydroxytestosterone + H2O + [oxidized NADPH-hemoprotein reductase]
(1a)
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-
PATHWAY SOURCE
PATHWAYS