Information on EC - methylated-DNA-[protein]-cysteine S-methyltransferase

for references in articles please use BRENDA:EC2.1.1.63
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EC Tree
IUBMB Comments
This protein is involved in the repair of methylated DNA. Unlike EC, DNA-3-methyladenine glycosidase I and EC, DNA-3-methyladenine glycosidase II, which remove the methylated base leaving an apurinic/apyrimidinic site, this enzyme transfers the methyl group from the methylated DNA to an internal cysteine residue, leaving an intact nucleotide. Since the methyl transfer is irreversible, the enzyme can only catalyse a single turnover.
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The enzyme appears in viruses and cellular organisms
Ada protein, Ada-C, AGAT, AGT, AGTendoV, alkylated DNA-protein alkyltransferase, alkylguanine transferase, ATASE, C-hAGT, carboxyl terminal domain of the inducible Escherichia coli ada alkyltransferase, more
DNA (containing 4-O-methylthymine) + protein L-cysteine = DNA (without 4-O-methylthymine) + protein S-methyl-L-cysteine
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DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
show the reaction diagram
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