Any feedback?
Literature summary for 2.7.11.20 extracted from
- Eukaryotic elongation factor 2 kinase (eEF2K) in cancer (2017), Cancers (Basel), 9, 162 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | - |
Homo sapiens |  |
| additional information | the enzyme is activated under conditions of stress, such as energy depletion or nutrient deprivation, which can arise in poorly-vascularised tumours | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| A-484954 | - |
Homo sapiens | |
| additional information | the enzyme is not inhibited by staurosporine | Homo sapiens | |
| NH125 | - |
Homo sapiens | |
| rottlerin | - |
Homo sapiens | |
| TX-1918 | - |
Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [elongation factor 2] | Homo sapiens | - |
ADP + [elongation factor 2] phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O00418 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | the enzyme autophosphorylates on Thr348. The enzyme is extensively regulated by phosphorylation. S6 kinase phosphorylates the enzyme on Ser366 and impairs its activation by Ca2+/calmodulin. Mammalian target of rapamycin complex 1 directly phosphorylates the enzyme on Ser78/Ser396 thereby negatively regulating the enzyme activity | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-549 cell | - |
Homo sapiens | - |
| breast cancer cell | - |
Homo sapiens | - |
| breast epithelial cell | - |
Homo sapiens | - |
| colonic cancer cell | - |
Homo sapiens | - |
| colorectal cancer cell | - |
Homo sapiens | - |
| glioma cell | - |
Homo sapiens | - |
| HCT-116 cell | - |
Homo sapiens | - |
| HT-29 cell | - |
Homo sapiens | - |
| lung cancer cell | - |
Homo sapiens | - |
| MCF-10A cell | - |
Homo sapiens | - |
| MCF-7 cell | - |
Homo sapiens | - |
| MDA-MB-468 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [elongation factor 2] | - |
Homo sapiens | ADP + [elongation factor 2] phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| eEF2K | - |
Homo sapiens |
| eukaryotic elongation factor 2 kinase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | the enzyme is overexpressed in many tumours/cancers | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | In many types of tumour cells, and likely in more advanced solid tumours, the enzyme helps protect cells against nutrient depletion and other stresses by slowing down protein synthesis (thereby conserving resources) and/or altering the translation rates of specific mRNAs and thus the levels of the corresponding proteins. The enzyme aids the growth of solid tumours in vivo and aids cell migration. The enzyme is required for the resistance of tumors to caloric restriction-induced cell death. The enzyme plays a role in protecting breast cancer cells against endoplasmic reticulum stress, apparently by activating autophagy | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
