Any feedback?
No. of entries
Information on EC 2.4.1.175 - glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
for references in articles please use BRENDA:EC2.4.1.175
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree 2 Transferases
2.4 Glycosyltransferases
2.4.1 Hexosyltransferases
2.4.1.175 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
IUBMB Comments
Involved in the biosynthesis of chondroitin sulfate. The human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-β-glucuronosyltransferase (EC 2.4.1.226, N-acetylgalactosaminyl-proteoglycan 3-β-glucuronosyltransferase) activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase ’co-polymerases’ can be found in Pasteurella multocida and Escherichia coli.
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
- 2.4.1.175
- glycosaminoglycans
- n-acetylgalactosamine
- udp-galnac
-
glcua
-
sulfotransferases
- medicine
-
glucuronyltransferase
- hexasaccharide
- udp-glca
- udp-sugars
-
d-glucuronic
-
chemo-enzymatically
- diagnostics
Reaction Schemes
show+
=
+
+
[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
=
+
[protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
+
=
+
+
[protein]-3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)]n-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
=
+
[protein]-3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)]n+1-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
Synonyms
chondroitin polymerase, chondroitin synthase-1, chsy-2, csgalnact-2, chondroitin synthase 1, n-acetylgalactosaminyltransferase ii, cs synthase-1, cs glycosyltransferase, more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin, II
-
-
-
-
ChGn-2
chondroitin galactosaminyltransferase
chondroitin polymerase
chondroitin sulfate N-acetylgalactosaminyltransferase-2
chondroitin sulfate synthase 1
chondroitin sulfate synthase-1
chondroitin sulfate synthase-2/chondroitin polymerizing factor
chondroitin sulfate synthase-3
chondroitin synthase
chondroitin synthase-2
based on the experimental results chondroitin sulfate synthase-3 is renamed into chondroitin synthase-2
chondroitin synthase-3
based on the experimental results CSGlcA-T renamed into chondroitin synthase-3
CHSY1
CpCS
Cpha266_2341
CSS2
CSS3
glucuronyl-N-acetylgalactosaminylproteoglycan beta1,4-N-acetylgalactosaminyltransferase
-
-
-
-
K4CP
N-acetylgalactosaminyltransferase II
-
-
-
-
UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase
-
-
-
-
uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferasec II
-
-
-
-
additional information
chondroitin synthase
-
-
-
-
additional information
-
the enzyme also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity
additional information
-
the human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase co-polymerases can be found in Pasteurella multocida and Escherichia coli.
additional information
the enzyme also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity
additional information
the human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase co-polymerases can be found in Pasteurella multocida and Escherichia coli.
additional information
the enzyme also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity
-
additional information
the human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase co-polymerases can be found in Pasteurella multocida and Escherichia coli.
-
additional information
the enzyme also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity
additional information
the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174
additional information
the human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase co-polymerases can be found in Pasteurella multocida and Escherichia coli.
additional information
the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174
additional information
the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174
additional information
the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174
additional information
the enzyme shows no 3-beta-glucuronosyltransferase activity, EC 2.4.1.226
additional information
the human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase co-polymerases can be found in Pasteurella multocida and Escherichia coli.
additional information
the human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase co-polymerases can be found in Pasteurella multocida and Escherichia coli.
additional information
the human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase co-polymerases can be found in Pasteurella multocida and Escherichia coli.
additional information
the enzyme also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity
additional information
the enzyme also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity
additional information
the human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase co-polymerases can be found in Pasteurella multocida and Escherichia coli.
additional information
the human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase co-polymerases can be found in Pasteurella multocida and Escherichia coli.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-galactosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
UDP-N-acetyl-alpha-D-galactosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)]n-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)]n+1-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
(2)
-
-
-
UDP-N-acetyl-alpha-D-galactosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
enzyme contains 2 distinct catalytic site for GalNAc and GlcNAc transferase activity
UDP-N-acetyl-alpha-D-galactosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
(1)
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexosyl group transfer
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
MetaCyc
chondroitin biosynthesis
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
Involved in the biosynthesis of chondroitin sulfate. The human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase (EC 2.4.1.226, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase) activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase 'co-polymerases' can be found in Pasteurella multocida and Escherichia coli.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
96189-40-1
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
alpha-thrombomodulin + UDP-N-acetyl-D-galactosamine + UDP-glucuronic acid
?
Substrates: -
Products: -
Products: -
?
chondroitin + UDP-GalNAc
?
Substrates: chondroitin is the best substrate
Products: -
Products: -
?
chondroitin + UDP-glucuronic acid
?
Substrates: chondroitin is the best substrate
Products: -
Products: -
?
chondroitin sulfate A + UDP-glucuronic acid
?
Substrates: -
Products: -
Products: -
?
chondroitin sulfate A10 + UDP-GalNAc
?
Substrates: no activity with UDP-glucuronic acid
Products: -
Products: -
?
chondroitin sulfate A11 + UDP-glucuronic acid
?
Substrates: no activity with UDP-GalNAc
Products: -
Products: -
?
chondroitin sulfate C + UDP-glucuronic acid
?
Substrates: -
Products: -
Products: -
?
chondroitin sulfate C10 + UDP-GalNAc
?
Substrates: no activity with UDP-glucuronic acid
Products: -
Products: -
?
chondroitin sulfate C11 + UDP-glucuronic acid
?
Substrates: no activity with UDP-GalNAc
Products: -
Products: -
?
chondroitin sulfate D + UDP-glucuronic acid
?
Substrates: -
Products: -
Products: -
?
chondroitin sulfate E + UDP-glucuronic acid
?
Substrates: -
Products: -
Products: -
?
GlcUAbeta1-3Galbeta1-O-C2H4NH-benzyloxycarbonyl + UDP-glucuronic acid
?
Substrates: -
Products: -
Products: -
?
GlcUAbeta1-3Galbeta1-O-C2H4NH-benzyloxycarbonyl + UDP-N-acetyl-D-galactosamine
?
Substrates: -
Products: -
Products: -
?
GlcUAbeta1-3Galbeta1-O-naphthalenemethanol + UDP-glucuronic acid
?
Substrates: -
Products: -
Products: -
?
GlcUAbeta1-3Galbeta1-O-naphthalenemethanol + UDP-N-acetyl-D-galactosamine
?
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-[GlcA-GalNAc]n-pyridylamine
UDP + [GlcA-GalNAc]n+1-pyridylamine
-
Substrates: -
Products: -
Products: -
?
UDP-GalNAc + 4-nitrophenyl D-glucuronide
UDP + 4-nitrophenyl 4-O-(N-acetyl-alpha-D-glucosaminyl)-D-glucuronide
UDP-glucuronic acid + chondroitin sulfate CS-11
?
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine 4-sulfate)4
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
-
Substrates: i.e. chondroitin sulfate octasaccharide, glycosylated at 32% the rate of chondroitin octasaccharide
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)2
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-glucuronyl-N-acetyl-1,3-beta-D-galactosamine
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)2
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)4
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)5
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)4
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)6
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)5
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)7
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)6
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)8
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)7
-
Substrates: i.e. chondroitin hexadecasaccharide, glycosylated at 15% the rate of decamer glycosylation
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-glucosamine)4
UDP + ?
-
Substrates: i.e. hyaluronate octasaccharide, glycosylated at 25% the rate of chondroitin octasaccharide
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
UDP-N-acetyl-alpha-D-galactosamine + chondroitin hexasaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin hexasaccharide
UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide
UDP-N-acetyl-alpha-D-galactosamine + chondroitin pentasaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin pentasaccharide
UDP-N-acetyl-alpha-D-galactosamine + chondroitin polysaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin polysaccharide
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
UDP-N-acetyl-alpha-D-galactosamine + [GlcA-GalNAc]n-pyridylamine
UDP + N-acetyl-beta-D-galactosaminyl-[GlcA-GalNAc]n-pyridylamine
UDP-N-acetyl-alpha-D-glucosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-glucosaminyl chondroitin sulfate oligosaccharide
UDP-N-acetyl-beta-D-galactosamine + chondroitin sulfate hexasaccharide
?
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
UDP-N-acetyl-D-galactosamine + chondroitin polysaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin polysaccharide
Substrates: best acceptor substrate
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin sulfate C
UDP + N-acetyl-D-galactosaminyl chondroitin sulfate C
UDP-N-acetyl-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin sulfate oligosaccharide
UDP-N-acetyl-D-galactosamine + defructosylated K4 oligosaccharide
UDP + N-acetyl-D-galactosaminyl defructosylated K4 oligosaccharide
UDP-alpha-D-glucuronate + chondroitin hexasaccharide
UDP + ?
-
Substrates: -
Products: -
Products: -
?
UDP-alpha-D-glucuronate + chondroitin hexasaccharide
UDP + ?
-
Substrates: -
Products: -
Products: -
?
UDP-GalNAc + 4-nitrophenyl D-glucuronide
UDP + 4-nitrophenyl 4-O-(N-acetyl-alpha-D-glucosaminyl)-D-glucuronide
Substrates: -
Products: -
Products: -
?
UDP-GalNAc + 4-nitrophenyl D-glucuronide
UDP + 4-nitrophenyl 4-O-(N-acetyl-alpha-D-glucosaminyl)-D-glucuronide
Substrates: -
Products: -
Products: -
?
UDP-GalNAc + 4-nitrophenyl D-glucuronide
UDP + 4-nitrophenyl 4-O-(N-acetyl-alpha-D-glucosaminyl)-D-glucuronide
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)2
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-glucuronyl-N-acetyl-1,3-beta-D-galactosamine
-
Substrates: i.e. chondroitin tetrasaccharide, glycosylated at 40% the rate of decamer glycosylation
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)2
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-glucuronyl-N-acetyl-1,3-beta-D-galactosamine
Substrates: minimal required acceptor substrate chain length
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)2
-
Substrates: minimal chain length required for activity
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)2
-
Substrates: i.e. chondroitin hexasaccharide, glycosylated at 60% the rate of decamer glycosylation
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)2
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)2
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)2
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)2
Substrates: low activity
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)4
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
-
Substrates: i.e. chondroitin octasaccharide, glycosylated at 75% the rate of decamer glycosylation
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)4
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)4
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)3
Substrates: low activity
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)5
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)4
-
Substrates: i.e. chondroitin decasaccharide, best substrate
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)5
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)4
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)6
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)5
-
Substrates: i.e. chondroitin dodecasaccharide, glycosylated at about 60% the rate of decamer glycosylation
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)6
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)5
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)7
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)6
-
Substrates: i.e. chondroitin tetradecasaccharide, glycosylated at about 45% the rate of decamer glycosylation
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + (glucuronyl-N-acetyl-1,3-beta-D-galactosamine)7
UDP + N-acetyl-beta-D-galactosaminyl-1,4-glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-(glucuronyl-N-acetyl-1,3-beta-D-galactosamine)6
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin hexasaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin hexasaccharide
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin hexasaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin hexasaccharide
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide
-
Substrates: involved in chondroitin biosynthesis
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide
-
Substrates: biosynthesis of K4 antigen, a capsule polysaccharide consisting of a chondroitin backbone to which beta-fructose is linked at position C-3 of the GlcNAc residue
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide
Substrates: biosynthesis of K4 antigen, a capsule polysaccharide consisting of a chondroitin backbone to which beta-fructose is linked at position C-3 of the GlcNAc residue
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide
Substrates: involved in chondroitin biosynthesis
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide
Substrates: involved in chondroitin biosynthesis
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin pentasaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin pentasaccharide
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin pentasaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin pentasaccharide
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin polysaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin polysaccharide
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin polysaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin polysaccharide
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
-
Substrates: involved in chondroitin sulfate biosynthesis: elongation of growing chondroitin sulfate chain
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
Substrates: involved in chondroitin sulfate biosynthesis: elongation of growing chondroitin sulfate chain
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
Substrates: involved in chondroitin sulfate biosynthesis: elongation of growing chondroitin sulfate chain
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + [GlcA-GalNAc]n-pyridylamine
UDP + N-acetyl-beta-D-galactosaminyl-[GlcA-GalNAc]n-pyridylamine
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-galactosamine + [GlcA-GalNAc]n-pyridylamine
UDP + N-acetyl-beta-D-galactosaminyl-[GlcA-GalNAc]n-pyridylamine
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-glucosamine + chondroitin
?
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-glucosamine + chondroitin
?
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-glucosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-glucosaminyl chondroitin sulfate oligosaccharide
-
Substrates: weak activity
Products: -
Products: -
?
UDP-N-acetyl-alpha-D-glucosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-beta-D-glucosaminyl chondroitin sulfate oligosaccharide
-
Substrates: weak activity
Products: -
Products: -
?
UDP-N-acetyl-beta-D-galactosamine + chondroitin
?
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-beta-D-galactosamine + chondroitin
?
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
-
Substrates: best acceptor substrate
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
-
Substrates: no substrates are glucuronyl-N-acetyl-1,3-beta-galactosamine or glucuronyl-N-acetyl-1,3-beta-D-galactosaminyl-N-acetyl-1,3-beta-D-galactosaminyl-N-acetyl-galactosaminol
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
-
Substrates: acceptors are even-numbered chondroitin oligosaccharides with terminal glucuronyl-N-acetyl-1,3-beta-D-galactosamine sequence at non-reducing end, transfers N-acetyl-galactosamine to non-reducing glucuronic acid residues in beta-glycosidic linkage
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
Substrates: acceptors are even-numbered chondroitin oligosaccharides with terminal glucuronyl-N-acetyl-1,3-beta-D-galactosamine sequence at non-reducing end, transfers N-acetyl-galactosamine to non-reducing glucuronic acid residues in beta-glycosidic linkage
Products: transfer in beta-1,4-linkage
Products: transfer in beta-1,4-linkage
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
-
Substrates: long polymers are not formed
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
-
Substrates: in vitro: addition of single sugars to a nonreducing terminal GlcNAc residue of a chondroitin-derived oligosaccharide acceptor
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
Substrates: acceptor substrates longer than a tetrasaccharide are absolutely required
Products: transfer in beta-1,4-linkage
Products: transfer in beta-1,4-linkage
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
-
Substrates: long polymers are not formed
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
-
Substrates: in vitro: addition of single sugars to a nonreducing terminal GlcNAc residue of a chondroitin-derived oligosaccharide acceptor
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
Substrates: acceptors are even-numbered chondroitin oligosaccharides with terminal glucuronyl-N-acetyl-1,3-beta-D-galactosamine sequence at non-reducing end, transfers N-acetyl-galactosamine to non-reducing glucuronic acid residues in beta-glycosidic linkage
Products: transfer in beta-1,4-linkage
Products: transfer in beta-1,4-linkage
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
Substrates: acceptor substrates longer than a tetrasaccharide are absolutely required
Products: transfer in beta-1,4-linkage
Products: transfer in beta-1,4-linkage
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
Substrates: low activity
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
Substrates: best acceptor substrate
Products: transfer in beta-1,4-linkage
Products: transfer in beta-1,4-linkage
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
Substrates: best acceptor substrate
Products: transfer in beta-1,4-linkage
Products: transfer in beta-1,4-linkage
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
Substrates: acceptors are even-numbered chondroitin oligosaccharides with terminal glucuronyl-N-acetyl-1,3-beta-D-galactosamine sequence at non-reducing end, transfers N-acetyl-galactosamine to non-reducing glucuronic acid residues in beta-glycosidic linkage
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
Substrates: high specificity for sugar donor substrates
Products: transfer in beta-1,4-linkage
Products: transfer in beta-1,4-linkage
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
Substrates: in vitro: addition of single sugars to a nonreducing terminal GlcNAc residue of a chondroitin-derived oligosaccharide acceptor
Products: transfer in beta-1,4-linkage
Products: transfer in beta-1,4-linkage
?
UDP-N-acetyl-D-galactosamine + chondroitin oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin oligosaccharide
-
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin sulfate C
UDP + N-acetyl-D-galactosaminyl chondroitin sulfate C
-
Substrates: no activity
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin sulfate C
UDP + N-acetyl-D-galactosaminyl chondroitin sulfate C
-
Substrates: no activity
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin sulfate C
UDP + N-acetyl-D-galactosaminyl chondroitin sulfate C
Substrates: 11% activity compared to chondroitin
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin sulfate C
UDP + N-acetyl-D-galactosaminyl chondroitin sulfate C
Substrates: no activity
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin sulfate oligosaccharide
-
Substrates: no activity
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin sulfate oligosaccharide
Substrates: acceptor substrates longer than a tetrasaccharide are absolutely required
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin sulfate oligosaccharide
-
Substrates: no activity
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin sulfate oligosaccharide
Substrates: acceptor substrates longer than a tetrasaccharide are absolutely required
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin sulfate oligosaccharide
Substrates: -
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + chondroitin sulfate oligosaccharide
UDP + N-acetyl-D-galactosaminyl chondroitin sulfate oligosaccharide
Substrates: no activity
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + defructosylated K4 oligosaccharide
UDP + N-acetyl-D-galactosaminyl defructosylated K4 oligosaccharide
-
Substrates: the native K4 oligosaccharide, containing a fructose residue branch at C-3 of each GlcNAc residue of the chondroitin backbone, is no substrate
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + defructosylated K4 oligosaccharide
UDP + N-acetyl-D-galactosaminyl defructosylated K4 oligosaccharide
-
Substrates: in vitro: addition of single sugars to a nonreducing terminal GlcNAc residue of a chondroitin-derived oligosaccharide acceptor, but long polymers are not formed
Products: -
Products: -
?
UDP-N-acetyl-D-galactosamine + defructosylated K4 oligosaccharide
UDP + N-acetyl-D-galactosaminyl defructosylated K4 oligosaccharide
-
Substrates: the native K4 oligosaccharide, containing a fructose residue branch at C-3 of each GlcNAc residue of the chondroitin backbone, is no substrate
Products: -
Products: -
?
additional information
?
-
Substrates: GlcA with a para-nitrophenyl group can serve as the acceptor for ApCS. The enzyme shows a stringent donor tolerance when the acceptor is as small as this monosaccharide. Ligand/substrate interaction analysis via surface plasmon resonance (SPR) analysis. Substrate specificity, overview. GlcA-pNP can serve as the acceptor for ApCS
Products: -
Products: -
-
additional information
?
-
Substrates: GlcA with a para-nitrophenyl group can serve as the acceptor for ApCS. The enzyme shows a stringent donor tolerance when the acceptor is as small as this monosaccharide. Ligand/substrate interaction analysis via surface plasmon resonance (SPR) analysis. Substrate specificity, overview. GlcA-pNP can serve as the acceptor for ApCS
Products: -
Products: -
-
additional information
?
-
Substrates: GlcA with a para-nitrophenyl group can serve as the acceptor for ApCS. The enzyme shows a stringent donor tolerance when the acceptor is as small as this monosaccharide. Ligand/substrate interaction analysis via surface plasmon resonance (SPR) analysis. Substrate specificity, overview. GlcA-pNP can serve as the acceptor for ApCS
Products: -
Products: -
-
additional information
?
-
-
Substrates: chondroitin sulfates A, C, D, and E, and dermatan sulfate are poor acceptor substrates
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity
Products: -
Products: -
?
additional information
?
-
Substrates: analysis of acceptor and donor substrate specificity, product analysis by gel filtration, overview. No substantial incorporation of radiolabeled [3H]GlcA into polymer is observed if UDP-GalNAc is omitted, although very low incorporation is detected when UDP-GlcNAc, the C4 epimer used as an HA polymer donor, is substituted for UDP-GalNAc. The recombinant enzyme shows negligible activity with UDP-Glc and UDP-Gal, and no activity with UDP-GlcA and UDP-GalA. The enzyme shows no de novo initiation of chondroitin sulfate synthesis. It is active with the cognate chondroitin tetrasaccharide acceptor. The Chlorobium CpCS enzyme readily extends hyaluronan or heparosan with longer chondroitin chains
Products: -
Products: -
-
additional information
?
-
Substrates: analysis of acceptor and donor substrate specificity, product analysis by gel filtration, overview. No substantial incorporation of radiolabeled [3H]GlcA into polymer is observed if UDP-GalNAc is omitted, although very low incorporation is detected when UDP-GlcNAc, the C4 epimer used as an HA polymer donor, is substituted for UDP-GalNAc. The recombinant enzyme shows negligible activity with UDP-Glc and UDP-Gal, and no activity with UDP-GlcA and UDP-GalA. The enzyme shows no de novo initiation of chondroitin sulfate synthesis. It is active with the cognate chondroitin tetrasaccharide acceptor. The Chlorobium CpCS enzyme readily extends hyaluronan or heparosan with longer chondroitin chains
Products: -
Products: -
-
additional information
?
-
Substrates: the enzyme also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity
Products: -
Products: -
?
additional information
?
-
-
Substrates: no hydrolysis activity is observed with UDP-N-glucuronic acid
Products: -
Products: -
?
additional information
?
-
-
Substrates: no hydrolysis activity is observed with UDP-N-glucuronic acid
Products: -
Products: -
?
additional information
?
-
Substrates: the enzyme also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity
Products: -
Products: -
?
additional information
?
-
Substrates: low activity with sulfated oligosaccharide substrates
Products: -
Products: -
?
additional information
?
-
Substrates: the enzyme shows no 3-beta-glucuronosyltransferase activity, EC 2.4.1.226
Products: -
Products: -
?
additional information
?
-
Substrates: the enzyme shows no 3-beta-glucuronosyltransferase activity, EC 2.4.1.226
Products: -
Products: -
?
additional information
?
-
Substrates: the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174
Products: -
Products: -
?
additional information
?
-
Substrates: the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174
Products: -
Products: -
?
additional information
?
-
Substrates: the enzyme also has N-acetylgalactosaminyltransferase I activity, EC 2.4.1.174
Products: -
Products: -
?
additional information
?
-
Substrates: chondroitin sulfates A, C, D, and E, and dermatan sulfate are poor acceptor substrates
Products: -
Products: -
?
additional information
?
-
Substrates: the enzyme also has the 3-beta-glucuronosyltransferase, EC 2.4.1.226, activity
Products: -
Products: -
?
additional information
?
-
Substrates: chondroitin sulfate A and D are very poor acceptor substrates
Products: -
Products: -