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Literature summary for 2.8.2.17 extracted from

  • Pan, H.; Xue, W.; Zhao, W.; Schachner, M.
    Expression and function of chondroitin 4-sulfate and chondroitin 6-sulfate in human glioma (2020), FASEB J., 34, 2853-2868 .
    View publication on PubMed
Search for more literature for 2.8.2.17

Cloned(Commentary)

Cloned (Comment) Organism
gene CHST3, real-time PCR enzyme expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information enzyme knockout by siRNA Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + chondroitin Homo sapiens
-
 adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q7LGC8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
glioma cell
-
 Homo sapiens
-
U-251MG cell
-
 Homo sapiens
-
U-87MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + chondroitin
-
 Homo sapiens adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
C6ST-1
-
 Homo sapiens
chondroitin 6-O-sulfotransferase-1
-
 Homo sapiens
CHST3
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction C6ST-1 activity and C6S production are upregulated in human glioma tissues, when compared to normal brain tissue, and the extent of upregulation positively correlates with glioma malignancy. Inhibition of expression of the two CS synthetic enzymes chondroitin 4-O-sulfotransferase-1 (C4ST-1/CHST11, EC 2.8.2.5) and chondroitin 6-O-sulfotransferase-1 (C6ST-1/CHST3) suppress cell viability, migration and invasion, reduce MMP-2 and MMP-9 expression, and reduce N-cadherin expression, but increase E-cadherin levels. Clinicopathological features, overview Homo sapiens
physiological function key molecules promoting migration and invasion exist in the extracellular matrix, and include chondroitin 4-sulfate (C4S) and chondroitin 6-sulfate (C6S), functionally important carbohydrate chains of chondroitin sulfate proteoglycans that participate in regulating cancer development. The C4S- and C6S-enhanced epithelial-tomesenchymal transition and expression of MMP-2 occur via activation of the PI3K/AKT signaling pathway, known to be involved in promoting cell migration and invasion. C4S and C6S increase the numbers of living glioma cells and promote proliferation, they promote colony formation of glioma cells, phenotypes, overview Homo sapiens