Application | Comment | Organism |
---|---|---|
medicine | high enzyme expression is significantly associated with the grade of malignancy and poor prognosis in glioma patients. The enzyme is a therapeutic target for treatment of glioma | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acylglycerol | Homo sapiens | - |
ADP + lysophosphatidic acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q53H12 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioma cell | - |
Homo sapiens | - |
U-251MG cell | - |
Homo sapiens | - |
U-87MG cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acylglycerol | - |
Homo sapiens | ADP + lysophosphatidic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AGK | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme expression, at both mRNA and protein levels, are markedly upregulated in glioma tissues compared with non-neoplastic brain tissues | up |
General Information | Comment | Organism |
---|---|---|
malfunction | silencing the expression of the enzyme dramatically suppresses cell proliferation, migration and invasion of glioma cells in vitro | Homo sapiens |
physiological function | the enzyme plays an important role in the viability and motility of glioma cells. Enzyme upregulation is involved into glioma development and progression | Homo sapiens |