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Information on EC 2.7.11.20 - elongation factor 2 kinase
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2.7.11.20 elongation factor 2 kinaseIUBMB Comments
Requires Ca2+ and calmodulin for activity. The enzyme can also be phosphorylated by the catalytic subunit of EC 2.7.11.11, cAMP-dependent protein kinase. Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca2+ [1,2].
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Word Map
- 2.7.11.20
- rapamycin
-
perk
- starvation
- mtor
- synaptic
-
heme-regulated
- autophosphorylation
-
uncharged
- eif4e
-
pkr-like
-
ido
-
autokinase
-
alpha-kinase
-
acid-starved
-
cam-dependent
- rottlerin
- medicine
-
histidyl-trna
- pharmacology
- agriculture
The enzyme appears in viruses and cellular organisms
Synonyms
eef2k, eef-2k, eif2alpha kinase, eef-2 kinase, eef2 kinase, eukaryotic elongation factor 2 kinase, gcn2 kinase, eukaryotic elongation factor-2 kinase, elongation factor-2 kinase, elongation factor 2 kinase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
eEF-2 kinase
EEF-2K
eEF2 kinase
eEF2K
elongation factor 2 kinase
elongation factor-2 kinase
eukaryotic elongation factor 2 kinase
eukaryotic elongation factor-2 kinase
GCN2
GCN2 eIF2alpha kinase
GCN2 kinase
general control nonderepressible 2 kinase
additional information
eEF2K
-
eukaryotic elongation factor 2 kinase
-
-
eukaryotic elongation factor 2 kinase
-
additional information
-
MHCKs and eEF-2Ks comprise a distinct subgroup within the alpha kinase famiily
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
phospho group transfer
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:[elongation factor 2] phosphotransferase
Requires Ca2+ and calmodulin for activity. The enzyme can also be phosphorylated by the catalytic subunit of EC 2.7.11.11, cAMP-dependent protein kinase. Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca2+ [1,2].
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CAS REGISTRY NUMBER
COMMENTARY
116283-83-1
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + acetyl-RKKYKFNEDTERRRFL-amide
ADP + acetyl-RKKYKFNED(phospho)TERRRFL-amide
-
-
-
?
ATP + cortactin
ADP + phosphorylated cortactin
i.e. SRC8, an Src substrate, phosphorylation peptide sequence is EYQGK-T-EKHAS
-
-
?
ATP + heat shock protein 60
ADP + phosphorylated heat shock protein 60
i.e. HSPD1, phosphorylation peptide sequence is TKDGV-T-VAKSI
-
-
?
ATP + hematological and neurological expressed 1-like protein
ADP + phosphorylated hematological and neurological expressed 1-like protein
i.e. HN1L, phosphorylation peptide sequence is FGSPV-T-ATSRL
-
-
?
ATP + heterogeneous nuclear ribonucleoprotein A1
ADP + phosphorylated heterogeneous nuclear ribonucleoprotein A1
i.e. HNRNPA1, phosphorylation peptide sequence is VSRED-S-QRPGA
-
-
?
ATP + immunoglobulin-binding protein 1
ADP + phosphorylated immunoglobulin-binding protein 1
i.e. IGBP1, phosphorylation peptide sequence is EDDEQ-T-LHRAR
-
-
?
ATP + microtubule-associated protein 4
ADP + phosphorylated microtubule-associated protein 4
i.e. MAP4, phosphorylation peptide sequence is TEAAA-T-TRKPE
-
-
?
ATP + N-myc downstream-regulated gene 1 protein
ADP + phosphorylated N-myc downstream-regulated gene 1 protein
i.e. NDRG1, phosphorylation peptide sequence is TSLDG-T-RSRSH
-
-
?
ATP + PEST proteolytic signal-containing nuclear protein
ADP + phosphorylated PEST proteolytic signal-containing nuclear protein
i.e. PCNP, phosphorylation peptide sequence is AIGSQ-T-TKKAS
-
-
?
ATP + prothymosin alpha
ADP + phosphorylated prothymosin alpha
i.e. PTMA, phosphorylation peptide sequence is TSSEI-T-TKDLK
-
-
?
ATP + SAP domain-containing ribonucleoprotein
ADP + phosphorylated SAP domain-containing ribonucleoprotein
i.e. SARNP, phosphorylation peptide sequence is GTTED-T-EAKKR
-
-
?
ATP + scaffold attachment factor B2
ADP + phosphorylated scaffold attachment factor B2
i.e. SAFB2, phosphorylation peptide sequence is VISVK-T-TSRSK
-
-
?
ATP + U4/U6 small nuclear ribonucleoprotein Prp31
ADP + phosphorylated U4/U6 small nuclear ribonucleoprotein Prp31
i.e. PRP31, phosphorylation peptide sequence is ERLGL-T-EIRKQ
-
-
?
ATP + [elongation factor 3]
ADP + [elongation factor 3]phosphate
-
-
-
-
?
ATP + [elongation translation factor 2]
ADP + [elongation translation factor 2]phosphate
-
-
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
ATP + [eukaryotic translation initiation factor 2alpha]
ADP + [eukaryotic translation initiation factor 2alpha]phosphate
ATP + [eukaryotic translation initiation factor 2]
ADP + [eukaryotic translation initiation factor 2]phosphate
ATP + [MHCK A peptide substrate]
ADP + [MHCK A peptide substrate] phosphate
-
i.e. YAYDTRYRR
-
-
?
ATP + MH-1 peptide
ADP + phosphorylated MH-1 peptide
-
the MH-1 peptide amino acid sequence is RKKFGESEKTKTKEFL
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
Thr348, and presumably its autophosphorylation, are critical for the ability of the enzyme to phosphorylate substrates in trans
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
the calmodulin-binding/alpha-kinase domain of the enzyme itself possesses autokinase activity, but is unable to phosphorylate substrates in trans. The phosphorylation of substrates in trans requires the SEL1-like domains of eEF2K
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
the recombinant human enzyme is able to phosphorylate wheat germ elongation factor 2 with kinetic parameters comparable to the mammalian enzyme
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
the enzyme phosphorylates elongation factor 2 at Ser56 and Thr58
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
phosphorylation at Thr56
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
phosphorylation at Thr56
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
the phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 is a key point of regulation of protein synthesis and amino acid homoeostasis in eukaryotes
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
phosphorylation at Thr57 inhibits the elongation factor 2 and blocks translational elongation, enzyme activity is regulated by rampamycin, 5-hydroxytryptamine, and serotonin, regulation mechanism
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
phosphorylation at Thr57 inhibits the elongation factor 2
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
enzyme regulation by de-/phosphorylation, overview
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
enzyme regulation via de-/phosphorylations, especially at Ser78, involving several kinases is dependent on the cellular amino acid status, enzyme regulation, overview
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
phosphorylation at Thr56
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
elongation factor 2 regulates the translation elongation through mTOR, p38, and MEK pathways, and is modulated through protein phosphatase 2A, overview
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
phosphorylation at Thr56
-
-
?
ATP + [eukaryotic elongation factor 2]
ADP + [eukaryotic elongation factor 2] phosphate
-
-
-
?
ATP + [eukaryotic elongation factor 2]
ADP + [eukaryotic elongation factor 2] phosphate
eukaryotic elongation factor 2 is inactivated when it is phosphorylated on Thr56 by the enzyme
-
-
?
ATP + [eukaryotic elongation factor 2]
ADP + [eukaryotic elongation factor 2] phosphate
-
-
-
?
ATP + [eukaryotic elongation factor 2]
ADP + [eukaryotic elongation factor 2] phosphate
the enzyme phosphorylates Thr56 of eukaryotic elongation factor 2
-
-
?
ATP + [eukaryotic elongation factor 2]
ADP + [eukaryotic elongation factor 2] phosphate
-
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
phosphorylation at Thr56
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
eEF2 is involved in eEF2 in neurite outgrowth regulation mechanism, since phosphorylated eEF2 inhibits mRNA translation via inhibition of eEF2-ribosome binding, calcium elevation appears to inhibit mRNA translation in growth cones by a synergistic mechanism involving regulation of EF2K, S6K, and eEF2 itself, overview
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
-
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
phosphorylation at Thr56
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
phosphorylation at Thr56
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
eEF2 is involved in eEF2 in neurite outgrowth regulation mechanism, since phosphorylated eEF2 inhibits mRNA translation via inhibition of eEF2-ribosome binding, calcium elevation appears to inhibit mRNA translation in growth cones by a synergistic mechanism involving regulation of EF2K, S6K, and eEF2 itself, overview
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
high glucose and high insulin regulate phosphorylation of eEF2 and eEF2 kinase by rapidly increasing activating Thr56 dephosphorylation of eEF2 and inactivating Ser366 phosphorylation of eEF2 kinase, events that facilitate elongation, overview
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
inhibition of eEF2 phosphorylation leads to increased activity of its upstream regulators AMP-activated protein kinase, AMPK, and eEF2 kinase, eEF2K, regulation, overview
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
the enzyme is involved in eukaryotic elongation factor 2 kinase in ER stress-induced signaling and cell death by inducing stress factors, regulation cascade, overview
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
the reaction leads to derepression of transcription factor GCN4
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
i.e. eEF2, both AMP-activated protein kinase, AMPK, and eEF2 kinase, eEF2K, phosphorylate eEF2, thus two distinct paths lead to eEF2 phosphorylation, overview
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
the enzyme exhibits strong preference for threonine as the phosphoacceptor amino acid, substrate specificity and phosphoacceptor amino acid specificity, overview
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
-
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
the reaction leads to derepression of transcription factor GCN4
-
-
?
ATP + [eukaryotic translation initiation factor 2alpha]
ADP + [eukaryotic translation initiation factor 2alpha]phosphate
-
-
-
-
?
ATP + [eukaryotic translation initiation factor 2alpha]
ADP + [eukaryotic translation initiation factor 2alpha]phosphate
-
GCN2 mediates translational control of gene expressionin amino acid-starved cells by phosphorylation of the eukaryotic translation initiation factor 2alpha associated to polyribosome and the regulatory GCN1-GCN20 complex, overview
-
-
?
ATP + [eukaryotic translation initiation factor 2]
ADP + [eukaryotic translation initiation factor 2]phosphate
-
-
-
?
ATP + [eukaryotic translation initiation factor 2]
ADP + [eukaryotic translation initiation factor 2]phosphate
-
-
-
?
additional information
?
-
-
SCH66336, a farnesyltransferase inhibitor, induces rapid phosphorylation and inhibition of eukaryotic translation elongation factor 2 in head and squamous cell carcinoma cells leading to growth inhibition in the cancer cells, the inhibitor functions independently of the signaling cascade involving the eEF2 kinase and its activators phosphorylated p70S6K and phosphorylated MEK
-
-
?
additional information
?
-
-
the enzyme expression and activity is increased in several forms of malignancy and human cancer, non-specific inhibitors of the enzyme cause cell death
-
-
?
additional information
?
-
-
the enzyme regulates protein synthesis in skeletal muscle
-
-
?
additional information
?
-
-
unphosphorylated elongation factor 2 promotes translational elongation, phosphorylation by the eEF2-kinase inhibits it, eEF2-kinase phosphorylated elongation factor 2 is further phosphorylated by cAMP-dependent protein kinase, EC 2.7.11.11, upon forskolin treatment leading to inhibition of elongation of cyclin D3 in T-lymphocytes, overview
-
-
?
additional information
?
-
the calcium/calmodulin-dependent kinase phosphorylates and inactivates eukaryotic elongation factor 2 and is subject to multisite phosphorylation, which regulates its activity. Phosphorylation at Ser359 by cyclin-dependent kinase 1, as cdc2cyclin B complexe, inactivates the enzyme occuring early in mitosis probably to keep the elongation factor 2 active during mitosis, overview
-
-
?
additional information
?
-
mammalian enzyme elongation factor-2 kinase (eEF2K) a requirement for threonine residues as the target of phosphorylation
-
-
?
additional information
?
-
the enzyme performs autophosphorylation at Thr57. Additional enzyme protein substrates show a strong sequence motif consisting of acidic residues in the -2 position and basic residues in the +3 position and almost exclusively threonine as the phosphorylated residue, peptide mapping and mass spectrometry analysis, overview
-
-
?
additional information
?
-
the enzyme performs autophosphorylation on residue Thr348
-
-
?
additional information
?
-
-
rottlerin suppresses eEF2K, but not eEF2 phosphorylation in myocytes
-
-
?
additional information
?
-
-
the GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of the essential amino acid leucine, thus, the enzyme acts as sensor for amino acid deficiency, overview
-
-
?
additional information
?
-
-
a lysine or arginine in the P+1 position on the C-terminal side of the phosphoacceptor threonine, P site, is critical for peptide substrate recognition by eEF-2K, eEF-2K requires basic residues in both the P+1 and P+3 positions to recognize peptide substrates, overview
-
-
?
additional information
?
-
-
non-muscle myosin II is a poor substrate for eEF-2 kinase, while eukaryotic elongation factor 2 is no substrate of kinase TRPM7
-
-
?
additional information
?
-
-
the GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of the essential amino acid leucine, thus, the enzyme acts as sensor for amino acid deficiency, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + [elongation factor 3]
ADP + [elongation factor 3]phosphate
-
-
-
-
?
ATP + [elongation translation factor 2]
ADP + [elongation translation factor 2]phosphate
-
-
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
ATP + [eukaryotic translation initiation factor 2alpha]
ADP + [eukaryotic translation initiation factor 2alpha]phosphate
-
GCN2 mediates translational control of gene expressionin amino acid-starved cells by phosphorylation of the eukaryotic translation initiation factor 2alpha associated to polyribosome and the regulatory GCN1-GCN20 complex, overview
-
-
?
ATP + [eukaryotic translation initiation factor 2]
ADP + [eukaryotic translation initiation factor 2]phosphate
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
the enzyme phosphorylates elongation factor 2 at Ser56 and Thr58
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
phosphorylation at Thr56
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
phosphorylation at Thr56
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2] phosphate
-
the phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 is a key point of regulation of protein synthesis and amino acid homoeostasis in eukaryotes
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
phosphorylation at Thr57 inhibits the elongation factor 2 and blocks translational elongation, enzyme activity is regulated by rampamycin, 5-hydroxytryptamine, and serotonin, regulation mechanism
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
enzyme regulation by de-/phosphorylation, overview
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
enzyme regulation via de-/phosphorylations, especially at Ser78, involving several kinases is dependent on the cellular amino acid status, enzyme regulation, overview
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
phosphorylation at Thr56
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
-
-
-
?
ATP + [elongation factor 2]
ADP + [elongation factor 2]phosphate
-
elongation factor 2 regulates the translation elongation through mTOR, p38, and MEK pathways, and is modulated through protein phosphatase 2A, overview
-
-
?
ATP + [eukaryotic elongation factor 2]
ADP + [eukaryotic elongation factor 2] phosphate
-
-
-
?
ATP + [eukaryotic elongation factor 2]
ADP + [eukaryotic elongation factor 2] phosphate
eukaryotic elongation factor 2 is inactivated when it is phosphorylated on Thr56 by the enzyme
-
-
?
ATP + [eukaryotic elongation factor 2]
ADP + [eukaryotic elongation factor 2] phosphate
-
-
-
?
ATP + [eukaryotic elongation factor 2]
ADP + [eukaryotic elongation factor 2] phosphate
the enzyme phosphorylates Thr56 of eukaryotic elongation factor 2
-
-
?
ATP + [eukaryotic elongation factor 2]
ADP + [eukaryotic elongation factor 2] phosphate
-
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
eEF2 is involved in eEF2 in neurite outgrowth regulation mechanism, since phosphorylated eEF2 inhibits mRNA translation via inhibition of eEF2-ribosome binding, calcium elevation appears to inhibit mRNA translation in growth cones by a synergistic mechanism involving regulation of EF2K, S6K, and eEF2 itself, overview
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
-
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
eEF2 is involved in eEF2 in neurite outgrowth regulation mechanism, since phosphorylated eEF2 inhibits mRNA translation via inhibition of eEF2-ribosome binding, calcium elevation appears to inhibit mRNA translation in growth cones by a synergistic mechanism involving regulation of EF2K, S6K, and eEF2 itself, overview
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
high glucose and high insulin regulate phosphorylation of eEF2 and eEF2 kinase by rapidly increasing activating Thr56 dephosphorylation of eEF2 and inactivating Ser366 phosphorylation of eEF2 kinase, events that facilitate elongation, overview
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
inhibition of eEF2 phosphorylation leads to increased activity of its upstream regulators AMP-activated protein kinase, AMPK, and eEF2 kinase, eEF2K, regulation, overview
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
the enzyme is involved in eukaryotic elongation factor 2 kinase in ER stress-induced signaling and cell death by inducing stress factors, regulation cascade, overview
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
the reaction leads to derepression of transcription factor GCN4
-
-
?
ATP + [eukaryotic translation elongation factor 2]
ADP + [eukaryotic translation elongation factor 2] phosphate
-
the reaction leads to derepression of transcription factor GCN4
-
-
?
ATP + [eukaryotic translation initiation factor 2]
ADP + [eukaryotic translation initiation factor 2]phosphate
-
-
-
?
ATP + [eukaryotic translation initiation factor 2]
ADP + [eukaryotic translation initiation factor 2]phosphate
-
-
-
?
additional information
?
-
-
SCH66336, a farnesyltransferase inhibitor, induces rapid phosphorylation and inhibition of eukaryotic translation elongation factor 2 in head and squamous cell carcinoma cells leading to growth inhibition in the cancer cells, the inhibitor functions independently of the signaling cascade involving the eEF2 kinase and its activators phosphorylated p70S6K and phosphorylated MEK
-
-
?
additional information
?
-
-
the enzyme expression and activity is increased in several forms of malignancy and human cancer, non-specific inhibitors of the enzyme cause cell death
-
-
?
additional information
?
-
-
the enzyme regulates protein synthesis in skeletal muscle
-
-
?
additional information
?
-
-
unphosphorylated elongation factor 2 promotes translational elongation, phosphorylation by the eEF2-kinase inhibits it, eEF2-kinase phosphorylated elongation factor 2 is further phosphorylated by cAMP-dependent protein kinase, EC 2.7.11.11, upon forskolin treatment leading to inhibition of elongation of cyclin D3 in T-lymphocytes, overview
-
-
?
additional information
?
-
the calcium/calmodulin-dependent kinase phosphorylates and inactivates eukaryotic elongation factor 2 and is subject to multisite phosphorylation, which regulates its activity. Phosphorylation at Ser359 by cyclin-dependent kinase 1, as cdc2cyclin B complexe, inactivates the enzyme occuring early in mitosis probably to keep the elongation factor 2 active during mitosis, overview
-
-
?
additional information
?
-
mammalian enzyme elongation factor-2 kinase (eEF2K) a requirement for threonine residues as the target of phosphorylation
-
-
?
additional information
?
-
-
rottlerin suppresses eEF2K, but not eEF2 phosphorylation in myocytes
-
-
?
additional information
?
-
-
the GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of the essential amino acid leucine, thus, the enzyme acts as sensor for amino acid deficiency, overview
-
-
?
additional information
?
-
-
the GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of the essential amino acid leucine, thus, the enzyme acts as sensor for amino acid deficiency, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE