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Information on EC 7.6.2.2 - ABC-type xenobiotic transporter

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IUBMB Comments
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. The enzymes from Gram-positive bacteria and eukaryotic cells export a number of drugs with unusual specificity, covering various groups of unrelated substances while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them also transport glutathione---drug conjugates (see EC 7.6.2.3, ABC-type glutathione-S-conjugate transporter) while others also show some 'flippase' activity (cf. EC 7.6.2.1, P-type phospholipid transporter).
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
+
+
xenobiotic[side 1]
=
+
+
xenobiotic[side 2]
Synonyms
ABC drug transporter, ABC multidrug efflux transporter, ABCB1, Abcb1a, ABCC1, ABCC10, ABCC2, ABCC3, ABCC4, ABCG2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + xenobiotic[side 1] = ADP + phosphate + xenobiotic[side 2]
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PATHWAY SOURCE
PATHWAYS