Inhibitors | Comment | Organism | Structure |
---|---|---|---|
orthovanadate | rapid and complete inhibition in the presence of ATP and Co2+, very stable Pgp-ADP-Vi-Co2+ complex | Cricetulus griseus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | transmembrane protein, location in the membrane | Cricetulus griseus | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Cricetulus griseus | the Pgp multidrug transporter carries out ATP-driven cellular efflux of a wide variety of hydrophobic drugs, natural products and peptides | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Cricetulus griseus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + H2O + xenobiotic[side 1] = ADP + phosphate + xenobiotic[side 2] | mechanism | Cricetulus griseus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CHRB30 cell | Chinese hamster ovary cells | Cricetulus griseus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/in | Hoechst 33342 binding site, proximity of bound Hoechst 33342 to the ATPase catalytic sites places the drug binding site of P-glycoprotein within the cytoplasmic membrane leaflet, Cys-428 and Cys-1071 are within the catalytic sites of Pgp, one within each of the Walker A motifs of the nucleotide binding folds, mechanism | Cricetulus griseus | ADP + phosphate + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/out | - |
? | |
additional information | the Pgp multidrug transporter carries out ATP-driven cellular efflux of a wide variety of hydrophobic drugs, natural products and peptides | Cricetulus griseus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MDR | - |
Cricetulus griseus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Cricetulus griseus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Cricetulus griseus |