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Literature summary for 7.6.2.2 extracted from

  • Chen, Z.; Shi, T.; Zhang, L.; Zhu, P.; Deng, M.; Huang, C.; Hu, T.; Jiang, L.; Li, J.
    Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance A review of the past decade (2016), Cancer Lett., 370, 153-164 .
    View publication on PubMed
Search for more literature for 7.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
amlodipine
-
 Homo sapiens
atorvastatin
-
 Homo sapiens
azithromycin
-
 Homo sapiens
cyclosporin A
-
 Homo sapiens
dexniguldipine
-
 Homo sapiens
dipyridamole
-
 Homo sapiens
Disulfiram
-
 Homo sapiens
elacridar
-
 Homo sapiens
fumitremorgin C
-
 Homo sapiens
Furosemide
-
 Homo sapiens
GF120918
-
 Homo sapiens
glibenclamide
-
 Homo sapiens
LY335979
-
 Homo sapiens
LY475776
-
 Homo sapiens
MK-571
-
 Homo sapiens
MS-209
-
 Homo sapiens
nifedipine
-
 Homo sapiens
novobiocin
-
 Homo sapiens
OC144-093
-
 Homo sapiens
ortataxel
-
 Homo sapiens
pluronic L61
-
 Homo sapiens
probenecid
-
 Homo sapiens
PSC-833
-
 Homo sapiens
quinidine
-
 Homo sapiens
R101933
-
 Homo sapiens
reserpine
-
 Homo sapiens
ritonavir
-
 Homo sapiens
S9788
-
 Homo sapiens
tariquidar
-
 Homo sapiens
V-104
-
 Homo sapiens
verapamil
-
 Homo sapiens
VX-710
-
 Homo sapiens
XR-9576
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + xenobiotic[side 1] Homo sapiens
-
 ADP + phosphate + xenobiotic[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P08183
-
-
Homo sapiens Q2M3G0
-
-
Homo sapiens Q92887
-
-
Homo sapiens Q9UNQ0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
brain capillary endothelial cell line
-
 Homo sapiens
-
culture condition:CD4+ cell
-
 Homo sapiens
-
enterocyte
-
 Homo sapiens
-
gall bladder
-
 Homo sapiens
-
hepatocyte
-
 Homo sapiens
-
intestinal mucosa
-
 Homo sapiens
-
intestine
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lymphocyte
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
renal proximal tubule epithelial cell
-
 Homo sapiens
-
small intestine
-
 Homo sapiens
-
trophoblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + 4-aminohippurate[side 1] substrate for MPR2 Homo sapiens ADP + phosphate + 4-aminohippurate[side 2]
-
 ?
ATP + H2O + 5-fluorouracil[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + 5-fluorouracil[side 2]
-
 ?
ATP + H2O + actinomycin D[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + actinomycin D[side 2]
-
 ?
ATP + H2O + adevovir[side 1] substrate for MPR2 Homo sapiens ADP + phosphate + adevovir[side 2]
-
 ?
ATP + H2O + amiodarone[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + amiodarone[side 2]
-
 ?
ATP + H2O + ampicillin[side 1] substrate for MPR2 Homo sapiens ADP + phosphate + ampicillin[side 2]
-
 ?
ATP + H2O + amprenavir[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + amprenavir[side 2]
-
 ?
ATP + H2O + asimadoline[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + asimadoline[side 2]
-
 ?
ATP + H2O + azidopine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + azidopine[side 2]
-
 ?
ATP + H2O + azidothymidine[side 1] substrate for BCRP Homo sapiens ADP + phosphate + azidothymidine[side 2]
-
 ?
ATP + H2O + azithromycin[side 1] substrate for MPR2 Homo sapiens ADP + phosphate + azithromycin[side 2]
-
 ?
ATP + H2O + BCECF-acetoxymethylester[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + BCECF-acetoxymethylester[side 2]
-
 ?
ATP + H2O + bepridil[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + bepridil[side 2]
-
 ?
ATP + H2O + bisantrene[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + bisantrene[side 2]
-
 ?
ATP + H2O + calcein acetoxymethylester[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + calcein acetoxymethylester[side 2]
-
 ?
ATP + H2O + calcein-acetoxymethylester[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + calcein-acetoxymethylester[side 2]
-
 ?
ATP + H2O + cefodizime[side 1] substrate for MPR2 Homo sapiens ADP + phosphate + cefodizime[side 2]
-
 ?
ATP + H2O + cefoperazone[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + cefoperazone[side 2]
-
 ?
ATP + H2O + ceftriaxone[side 1] substrate for MPR2 Homo sapiens ADP + phosphate + ceftriaxone[side 2]
-
 ?
ATP + H2O + ceftriaxone[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + ceftriaxone[side 2]
-
 ?
ATP + H2O + cerivastatin[side 1] substrate for BCRP Homo sapiens ADP + phosphate + cerivastatin[side 2]
-
 ?
ATP + H2O + chlorambucil[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + chlorambucil[side 2]
-
 ?
ATP + H2O + chlorpromazine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + chlorpromazine[side 2]
-
 ?
ATP + H2O + chrysin[side 1] substrate for BCRP Homo sapiens ADP + phosphate + chrysin[side 2]
-
 ?
ATP + H2O + cidofovir[side 1] substrate for MPR2 Homo sapiens ADP + phosphate + cidofovir[side 2]
-
 ?
ATP + H2O + cimetidine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + cimetidine[side 2]
-
 ?
ATP + H2O + ciprofloxacin[side 1] substrate for BCRP Homo sapiens ADP + phosphate + ciprofloxacin[side 2]
-
 ?
ATP + H2O + cisplatin[side 1] substrate for P-glycoprotein and MPR2 Homo sapiens ADP + phosphate + cisplatin[side 2]
-
 ?
ATP + H2O + clarithromycin[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + clarithromycin[side 2]
-
 ?
ATP + H2O + colchicine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + colchicine[side 2]
-
 ?
ATP + H2O + cyclosporin A[side 1] substrate for P-glycoprotein and BCRP Homo sapiens ADP + phosphate + cyclosporin A[side 2]
-
 ?
ATP + H2O + cyclosporin H[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + cyclosporin H[side 2]
-
 ?
ATP + H2O + cytarabine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + cytarabine[side 2]
-
 ?
ATP + H2O + daunorubicin[side 1] substrate for P-glycoprotein and BCRP Homo sapiens ADP + phosphate + daunorubicin[side 2]
-
 ?
ATP + H2O + delavirdine[side 1] substrate for BCRP Homo sapiens ADP + phosphate + delavirdine[side 2]
-
 ?
ATP + H2O + digoxin[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + digoxin[side 2]
-
 ?
ATP + H2O + diltiazem[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + diltiazem[side 2]
-
 ?
ATP + H2O + docetaxel[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + docetaxel[side 2]
-
 ?
ATP + H2O + doxorubicin[side 1] substrate for P-glycoprotein, BCRP, and MPR2 Homo sapiens ADP + phosphate + doxorubicin[side 2]
-
 ?
ATP + H2O + doxycycline[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + doxycycline[side 2]
-
 ?
ATP + H2O + endosulfan[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + endosulfan[side 2]
-
 ?
ATP + H2O + epirubicin[side 1] substrate for P-glycoprotein, BCRP, and MPR2 Homo sapiens ADP + phosphate + epirubicin[side 2]
-
 ?
ATP + H2O + erythromycin[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + erythromycin[side 2]
-
 ?
ATP + H2O + ethinylestradiol-3-O-glucuronide[side 1] substrate for MPR2 Homo sapiens ADP + phosphate + ethinylestradiol-3-O-glucuronide[side 2]
-
 ?
ATP + H2O + etoposide[side 1] substrate for P-glycoprotein, BCRP, and MPR2 Homo sapiens ADP + phosphate + etoposide[side 2]
-
 ?
ATP + H2O + felodipine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + felodipine[side 2]
-
 ?
ATP + H2O + fentanyl[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + fentanyl[side 2]
-
 ?
ATP + H2O + fexofenadine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + fexofenadine[side 2]
-
 ?
ATP + H2O + FK506[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + FK506[side 2]
-
 ?
ATP + H2O + gefitinib[side 1] substrate for P-glycoprotein and BCRP Homo sapiens ADP + phosphate + gefitinib[side 2]
-
 ?
ATP + H2O + genistein-7-glucoside[side 1] substrate for MPR2 Homo sapiens ADP + phosphate + genistein-7-glucoside[side 2]
-
 ?
ATP + H2O + gramicidin A[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + gramicidin A[side 2]
-
 ?
ATP + H2O + gramicidin D[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + gramicidin D[side 2]
-
 ?
ATP + H2O + grepafloxacine[side 1] substrate for MPR2 Homo sapiens ADP + phosphate + grepafloxacine[side 2]
-
 ?
ATP + H2O + grepafloxacin[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + grepafloxacin[side 2]
-
 ?
ATP + H2O + Hoechst 33342[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + Hoechst 33342[side 2]
-
 ?
ATP + H2O + hydroxyurea[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + hydroxyurea[side 2]
-
 ?
ATP + H2O + imatinib[side 1] substrate for BCRP Homo sapiens ADP + phosphate + imatinib[side 2]
-
 ?
ATP + H2O + indinavir[side 1] substrate for MPR2 Homo sapiens ADP + phosphate + indinavir[side 2]
-
 ?
ATP + H2O + indinavir[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + indinavir[side 2]
-
 ?
ATP + H2O + irinotecan[side 1] substrate for P-glycoprotein, BCRP, and MPR2 Homo sapiens ADP + phosphate + irinotecan[side 2]
-
 ?
ATP + H2O + itraconazole[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + itraconazole[side 2]
-
 ?
ATP + H2O + ketoconazole[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + ketoconazole[side 2]
-
 ?
ATP + H2O + lamivudine[side 1] substrate for BCRP Homo sapiens ADP + phosphate + lamivudine[side 2]
-
 ?
ATP + H2O + leupeptin[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + leupeptin[side 2]
-
 ?
ATP + H2O + levofloxacin[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + levofloxacin[side 2]
-
 ?
ATP + H2O + lidocaine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + lidocaine[side 2]
-
 ?
ATP + H2O + lopinavir[side 1] substrate for MPR2 and BCRP Homo sapiens ADP + phosphate + lopinavir[side 2]
-
 ?
ATP + H2O + lopinavir[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + lopinavir[side 2]
-
 ?
ATP + H2O + lovastatin[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + lovastatin[side 2]
-
 ?
ATP + H2O + methotrexate[side 1] substrate for P-glycoprotein, BCRP, and MPR2 Homo sapiens ADP + phosphate + methotrexate[side 2]
-
 ?
ATP + H2O + methyl parathion[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + methyl parathion[side 2]
-
 ?
ATP + H2O + mitomycin C[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + mitomycin C[side 2]
-
 ?
ATP + H2O + mitoxantrone[side 1] substrate for P-glycoprotein, BCRP, and MPR2 Homo sapiens ADP + phosphate + mitoxantrone[side 2]
-
 ?
ATP + H2O + morphine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + morphine[side 2]
-
 ?
ATP + H2O + nelfinavir[side 1] substrate for MPR2 and BCRP Homo sapiens ADP + phosphate + nelfinavir[side 2]
-
 ?
ATP + H2O + nelfinavir[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + nelfinavir[side 2]
-
 ?
ATP + H2O + nicardipine[side 1] substrate for BCRP Homo sapiens ADP + phosphate + nicardipine[side 2]
-
 ?
ATP + H2O + nifedipine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + nifedipine[side 2]
-
 ?
ATP + H2O + nisoldipine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + nisoldipine[side 2]
-
 ?
ATP + H2O + nitrendipine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + nitrendipine[side 2]
-
 ?
ATP + H2O + norfloxacin[side 1] substrate for BCRP Homo sapiens ADP + phosphate + norfloxacin[side 2]
-
 ?
ATP + H2O + ofloxacin[side 1] substrate for BCRP Homo sapiens ADP + phosphate + ofloxacin[side 2]
-
 ?
ATP + H2O + olmesartan[side 1] substrate for MPR2 Homo sapiens ADP + phosphate + olmesartan[side 2]
-
 ?
ATP + H2O + ortataxel[side 1] substrate for BCRP Homo sapiens ADP + phosphate + ortataxel[side 2]
-
 ?
ATP + H2O + paraquat[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + paraquat[side 2]
-
 ?
ATP + H2O + pentazocine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + pentazocine[side 2]
-
 ?
ATP + H2O + pepstatin A[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + pepstatin A[side 2]
-
 ?
ATP + H2O + phenothiazine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + phenothiazine[side 2]
-
 ?
ATP + H2O + phloridzin[side 1] substrate for MPR2 Homo sapiens ADP + phosphate + phloridzin[side 2]
-
 ?
ATP + H2O + pravastatin[side 1] substrate for BCRP Homo sapiens ADP + phosphate + pravastatin[side 2]
-
 ?
ATP + H2O + propafenone[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + propafenone[side 2]
-
 ?
ATP + H2O + quercetin 4'-beta-glucoside[side 1] substrate for MPR2 Homo sapiens ADP + phosphate + quercetin 4'-beta-glucoside[side 2]
-
 ?
ATP + H2O + quercetin[side 1] substrate for BCRP Homo sapiens ADP + phosphate + quercetin[side 2]
-
 ?
ATP + H2O + quinidine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + quinidine[side 2]
-
 ?
ATP + H2O + ranitidine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + ranitidine[side 2]
-
 ?
ATP + H2O + reserpine[side 1] substrate for BCRP Homo sapiens ADP + phosphate + reserpine[side 2]
-
 ?
ATP + H2O + rhodamine 123[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + rhodamine 123[side 2]
-
 ?
ATP + H2O + rifampicin[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + rifampicin[side 2]
-
 ?
ATP + H2O + ritonavir[side 1] substrate for MPR2 Homo sapiens ADP + phosphate + ritonavir[side 2]
-
 ?
ATP + H2O + ritonavir[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + ritonavir[side 2]
-
 ?
ATP + H2O + rosuvastatin[side 1] substrate for BCRP Homo sapiens ADP + phosphate + rosuvastatin[side 2]
-
 ?
ATP + H2O + saquinavir[side 1] substrate for MPR2 Homo sapiens ADP + phosphate + saquinavir[side 2]
-
 ?
ATP + H2O + saquinavir[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + saquinavir[side 2]
-
 ?
ATP + H2O + simvastatin[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + simvastatin[side 2]
-
 ?
ATP + H2O + sirolimus[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + sirolimus[side 2]
-
 ?
ATP + H2O + SN-38[side 1] substrate for MPR2 and BCRP Homo sapiens ADP + phosphate + SN-38[side 2]
-
 ?
ATP + H2O + sparfloxacin[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + sparfloxacin[side 2]
-
 ?
ATP + H2O + tacrolimus[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + tacrolimus[side 2]
-
 ?
ATP + H2O + tamoxifen[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + tamoxifen[side 2]
-
 ?
ATP + H2O + temocaprilate[side 1] substrate for MPR2 Homo sapiens ADP + phosphate + temocaprilate[side 2]
-
 ?
ATP + H2O + teniposide[side 1] substrate for P-glycoprotein and BCRP Homo sapiens ADP + phosphate + teniposide[side 2]
-
 ?
ATP + H2O + terfenadine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + terfenadine[side 2]
-
 ?
ATP + H2O + tetracycline[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + tetracycline[side 2]
-
 ?
ATP + H2O + tiapamil[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + tiapamil[side 2]
-
 ?
ATP + H2O + topotecan[side 1] substrate for P-glycoprotein and BCRP Homo sapiens ADP + phosphate + topotecan[side 2]
-
 ?
ATP + H2O + trans-flupentixol[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + trans-flupentixol[side 2]
-
 ?
ATP + H2O + trifluoperazine[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + trifluoperazine[side 2]
-
 ?
ATP + H2O + valinomycin[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + valinomycin[side 2]
-
 ?
ATP + H2O + valspodar[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + valspodar[side 2]
-
 ?
ATP + H2O + verapamil[side 1] substrate for P-glycoprotein Homo sapiens ADP + phosphate + verapamil[side 2]
-
 ?
ATP + H2O + vinblastine[side 1] substrate for P-glycoprotein and MPR2 Homo sapiens ADP + phosphate + vinblastine[side 2]
-
 ?
ATP + H2O + vincristine[side 1] substrate for P-glycoprotein and MPR2 Homo sapiens ADP + phosphate + vincristine[side 2]
-
 ?
ATP + H2O + xenobiotic[side 1]
-
 Homo sapiens ADP + phosphate + xenobiotic[side 2]
-
 ?
ATP + H2O + zidovudine[side 1] substrate for BCRP Homo sapiens ADP + phosphate + zidovudine[side 2]
-
 ?

Subunits

Subunits Comment Organism
? x * 170000, P-glycoprotein , SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ABCB1
-
 Homo sapiens
ABCC2
-
 Homo sapiens
ABCG2
-
 Homo sapiens
BCRP
-
 Homo sapiens
breast cancer resistance protein
-
 Homo sapiens
canalicular multispecific organic anion transporter
-
 Homo sapiens
MDR-ABC transporter
-
 Homo sapiens
MOAT
-
 Homo sapiens
MRP2
-
 Homo sapiens
multidrug resistance-associated protein 2
-
 Homo sapiens
P-glycoprotein
-
 Homo sapiens
P-gp
-
 Homo sapiens