Application | Comment | Organism |
---|---|---|
medicine | Pgp plays a central role in compromising cancer chemotherapy and in modulating the bioavailability and distribution of therapeutic agents | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
MDR1 gene, expression in Saccharomyces cerevisiae | Homo sapiens |
pgp1 gene, expression in Chinese hamster ovary CR1R12 cells | Cricetulus griseus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | ATPase activity associated with P-glycoprotein is characterized by three drug-dependent phases: basal without drug, drug-activated, and drug-inhibited | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic data, kinetic model of drug transport | Cricetulus griseus | |
additional information | - |
additional information | kinetic data, kinetic model of drug transport | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Cricetulus griseus | 5886 | - |
plasma membrane | recombinant Pgp, expressed in Saccharomyces cerevisiae | Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | Pgp transports drugs out of cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Cricetulus griseus |
recombinant Pgp | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + H2O + xenobiotic[side 1] = ADP + phosphate + xenobiotic[side 2] | thermodynamic data of ATP hydrolysis, mechanism | Cricetulus griseus | |
ATP + H2O + xenobiotic[side 1] = ADP + phosphate + xenobiotic[side 2] | thermodynamic data of ATP hydrolysis, mechanism | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ovary | - |
Cricetulus griseus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/in | Hoechst 33342 | Homo sapiens | ADP + phosphate + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/out | - |
? | |
ATP + H2O + colchicine/in | - |
Homo sapiens | ADP + phosphate + colchicine/out | - |
? | |
ATP + H2O + rhodamine 123/in | - |
Homo sapiens | ADP + phosphate + rhodamine 123/out | - |
? | |
ATP + H2O + valinomycin/in | - |
Cricetulus griseus | ADP + phosphate + valinomycin/out | - |
? | |
ATP + H2O + valinomycin/in | - |
Homo sapiens | ADP + phosphate + valinomycin/out | - |
? | |
ATP + H2O + verapamil/in | - |
Cricetulus griseus | ADP + phosphate + verapamil/out | - |
? | |
ATP + H2O + verapamil/in | unlabeled and spin-labeled verapamil | Homo sapiens | ADP + phosphate + verapamil/out | - |
? | |
ATP + H2O + vinblastine/in | - |
Homo sapiens | ADP + phosphate + vinblastine/out | - |
? | |
ATP + H2O + xenobiotic/in | Pgp transports drugs out of cells, very broad specificity drug pump, thermodynamic analysis of ATP hydrolysis in the presence and absence of transport substrates, mechanism, model of drug transport | Homo sapiens | ADP + phosphate + xenobiotic/out | - |
? | |
ATP + H2O + xenobiotic/in | thermodynamic analysis of ATP hydrolysis in the presence and absence of transport substrates, mechanism | Cricetulus griseus | ADP + phosphate + xenobiotic/out | - |
? | |
additional information | Pgp transports drugs out of cells | Homo sapiens | ? | - |
? | |
additional information | ATPase activity associated with P-glycoprotein is characterized by three drug-dependent phases: basal without drug, drug-activated, and drug-inhibited, the basal ATPase activity is not a consequence of transport of an endogenous lipid or other substrate, but rather an intrinsic mechanistic property of enzyme | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ABCB1 | - |
Homo sapiens |
MDR1 | - |
Homo sapiens |
P-glycoprotein | - |
Homo sapiens |
PGP1 | - |
Cricetulus griseus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
35 | 37 | assay at | Cricetulus griseus |
35 | 37 | assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Cricetulus griseus | |
additional information | - |
additional information | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | 7.5 | assay at | Cricetulus griseus |
7.4 | 7.5 | assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | data for drug inhibition of the basal ATPase activity | Homo sapiens |