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Literature summary for 7.6.2.2 extracted from

  • Karla, P.K.; Quinn, T.L.; Herndon, B.L.; Thomas, P.; Pal, D.; Mitra, A.
    Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux (2009), J. Ocul. Pharmacol. Ther., 25, 121-132.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.6.2.2

Activating Compound

Activating Compound Comment Organism Structure
additional information no effect by glutathione Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
additional information no effect by glutathione Homo sapiens
additional information no effect by glutathione Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + acyclovir/in Oryctolagus cuniculus
-
 ADP + phosphate + acyclovir/out
-
 ?
ATP + H2O + bimatoprost/in Oryctolagus cuniculus
-
 ADP + phosphate + bimatoprost/out
-
 ?
ATP + H2O + latanoprost/in Oryctolagus cuniculus
-
 ADP + phosphate + latanoprost/out
-
 ?
ATP + H2O + p-methoxy-ethylamphetamine/in Homo sapiens
-
 ADP + phosphate + p-methoxy-ethylamphetamine/out
-
 ?
ATP + H2O + p-methoxy-ethylamphetamine/in Oryctolagus cuniculus cell resistance against the drug substrate is diminished by ATP depletion and enzyme inhibition ADP + phosphate + p-methoxy-ethylamphetamine/out
-
 ?
ATP + H2O + xenobiotic/in Homo sapiens
-
 ADP + phosphate + xenobiotic/out
-
 ?
ATP + H2O + xenobiotic/in Oryctolagus cuniculus
-
 ADP + phosphate + xenobiotic/out
-
 ?
additional information Homo sapiens MRP5 plays a role in the ocular drug efflux and conferring ocular drug resistance ?
-
 ?
additional information Oryctolagus cuniculus MRP5 plays a role in the ocular drug efflux lowering the permeability of antiviral and glaucoma drugs and conferring ocular drug resistance ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cornea endothelium and epithelium, immunohistochemic localization Homo sapiens
-
cornea endothelium and epithelium, immunohistochemic localization Oryctolagus cuniculus
-
endothelium
-
 Homo sapiens
-
endothelium
-
 Oryctolagus cuniculus
-
epithelium
-
 Homo sapiens
-
epithelium
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens
additional information
-
-
 Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + acyclovir/in
-
 Oryctolagus cuniculus ADP + phosphate + acyclovir/out
-
 ?
ATP + H2O + bimatoprost/in
-
 Oryctolagus cuniculus ADP + phosphate + bimatoprost/out
-
 ?
ATP + H2O + latanoprost/in
-
 Oryctolagus cuniculus ADP + phosphate + latanoprost/out
-
 ?
ATP + H2O + p-methoxy-ethylamphetamine/in
-
 Homo sapiens ADP + phosphate + p-methoxy-ethylamphetamine/out
-
 ?
ATP + H2O + p-methoxy-ethylamphetamine/in
-
 Oryctolagus cuniculus ADP + phosphate + p-methoxy-ethylamphetamine/out
-
 ?
ATP + H2O + p-methoxy-ethylamphetamine/in cell resistance against the drug substrate is diminished by ATP depletion and enzyme inhibition Oryctolagus cuniculus ADP + phosphate + p-methoxy-ethylamphetamine/out
-
 ?
ATP + H2O + para-methoxy-ethylamphetamine/in
-
 Homo sapiens ADP + phosphate + para-methoxy-ethylamphetamine/out
-
 ?
ATP + H2O + xenobiotic/in
-
 Homo sapiens ADP + phosphate + xenobiotic/out
-
 ?
ATP + H2O + xenobiotic/in
-
 Oryctolagus cuniculus ADP + phosphate + xenobiotic/out
-
 ?
additional information MRP5 plays a role in the ocular drug efflux and conferring ocular drug resistance Homo sapiens ?
-
 ?
additional information MRP5 plays a role in the ocular drug efflux lowering the permeability of antiviral and glaucoma drugs and conferring ocular drug resistance Oryctolagus cuniculus ?
-
 ?

Synonyms

Synonyms Comment Organism
MRP5
-
 Homo sapiens
MRP5
-
 Oryctolagus cuniculus
multidrug resistance associated protein 5
-
 Homo sapiens
multidrug resistance associated protein 5
-
 Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
ATP
-
 Oryctolagus cuniculus