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Literature summary for 7.6.2.2 extracted from

  • Zeng, H.; Liu, G.; Rea, P.A.; Kruh, G.D.
    Transport of amphipathic anions by human multidrug resistance protein 3 (2000), Cancer Res., 60, 4779-4784.
    View publication on PubMed
Search for more literature for 7.6.2.2

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0053
-
 leukotriene C4/in
-
 Homo sapiens
0.0057
-
 2,4-dinitrophenyl S-glutathione/in
-
 Homo sapiens
0.0256
-
 estradiol 17-beta-D-glucuronide/in
-
 Homo sapiens
0.248
-
 glycocholate/in
-
 Homo sapiens
0.776
-
 methotrexate/in
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens MRP3 is competent in the transport of glutathione S-conjugates, glucuronides and methotrexate, the enzyme is active in the transport of monoanionic human bile constituent glycocholate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 MRP3
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,4-dinitrophenyl S-glutathione/in + ATP + H2O
-
 Homo sapiens 2,4-dinitrophenyl S-glutathione/out + ADP + H2O
-
 ?
estradiol 17-beta-D-glucuronide/in + ATP + H2O
-
 Homo sapiens estradiol 17-beta-D-glucuronide/out + ADP + phosphate
-
 ?
glycocholate/in + ATP + H2O
-
 Homo sapiens glycocholate/out + ADP + phosphate
-
 ?
leukotriene C4/in + ATP + H2O
-
 Homo sapiens leukotriene C4/out + ADP + phosphate
-
 ?
methotrexate/in + ATP + H2O
-
 Homo sapiens methotrexate/out + ADP + phosphate
-
 ?
additional information MRP3 is competent in the transport of glutathione S-conjugates, glucuronides and methotrexate, the enzyme is active in the transport of monoanionic human bile constituent glycocholate Homo sapiens ?
-
 ?