Literature summary for 7.6.2.2 extracted from

Wu, C.P.; Hsiao, S.H.; Murakami, M.; Lu, Y.J.; Li, Y.Q.; Huang, Y.H.; Hung, T.H.; Ambudkar, S.V.; Wu, Y.S.
alpha-Mangostin reverses multidrug resistance by attenuating the function of the multidrug resistance-linked ABCG2 transporter (2017), Mol. Pharm., 14, 2805-2814 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
alpha-mangostin	effectively and selectively inhibits enzyme-mediated drug transport and reverses multidrug resistance in ABCG2-overexpressing cancer cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UNQ0	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood-brain barrier	-	Homo sapiens	-
intestine	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + iodoarylazidoprazosin[side 1]	-	Homo sapiens	ADP + phosphate + iodoarylazidoprazosin[side 2]	-	?

Synonyms

Synonyms	Comment	Organism
ABC drug transporter	-	Homo sapiens
ABCG2	-	Homo sapiens
ATP-binding cassette drug transporter	-	Homo sapiens

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Release 2023.1 (January 2023)