Activating Compound | Comment | Organism | Structure |
---|---|---|---|
GSH | transport of unconjugated chemotherapeutic agents requires cotransport of glutathione, GSH by itself is not a substrate | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
membrane | contains an additional third NH2-proximal membrane-spanning domain, not found in previously characterized ABC transporters. This domain, whose NH2-terminus is extracytolsolic, is essential for MRP-mediated transport activity | Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
190000 | - |
1 * 190000, MRP from lung cancer cell line, calculation from nucleotide sequence | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | - |
? | - |
? | |
additional information | Homo sapiens | the physiological function can range from a protective role in chemical toxicity and oxidative stress to mediation of inflammatory responses involving cysteinyl leukotrienes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung cancer cell line | - |
Homo sapiens | - |
RPMI-8226 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aflatoxin B1/in + ATP + H2O | - |
Homo sapiens | aflatoxin B1/out + ADP + phosphate | - |
? | |
cysteinyl leukotriene C4/in + ATP + H2O | - |
Homo sapiens | cysteinyl leukotriene C4/out + ADP + phosphate | - |
? | |
estradiol 17-beta-D-glucuronide/in + ATP + H2O | - |
Homo sapiens | estradiol 17-beta-D-glucuronide/out + ADP + phosphate | - |
? | |
additional information | - |
Mus musculus | ? | - |
? | |
additional information | the physiological function can range from a protective role in chemical toxicity and oxidative stress to mediation of inflammatory responses involving cysteinyl leukotrienes | Homo sapiens | ? | - |
? | |
vincristine/in + ATP + H2O | - |
Mus musculus | vincristine/out + ADP + phosphate | - |
? | |
vincristine/in + ATP + H2O | requires cotransport of GSH | Homo sapiens | vincristine/out + ADP + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | 1 * 190000, MRP from lung cancer cell line, calculation from nucleotide sequence | Homo sapiens |