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Literature summary for 7.6.2.2 extracted from

  • Cole, S.P.C.; Deeley, R.G.
    Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP (1998), Bioessays, 20, 931-940.
    View publication on PubMed
Search for more literature for 7.6.2.2

Activating Compound

Activating Compound Comment Organism Structure
GSH transport of unconjugated chemotherapeutic agents requires cotransport of glutathione, GSH by itself is not a substrate Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-
membrane contains an additional third NH2-proximal membrane-spanning domain, not found in previously characterized ABC transporters. This domain, whose NH2-terminus is extracytolsolic, is essential for MRP-mediated transport activity Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
190000
-
 1 * 190000, MRP from lung cancer cell line, calculation from nucleotide sequence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus
-
 ?
-
 ?
additional information Homo sapiens the physiological function can range from a protective role in chemical toxicity and oxidative stress to mediation of inflammatory responses involving cysteinyl leukotrienes ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung cancer cell line
-
 Homo sapiens
-
RPMI-8226 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aflatoxin B1/in + ATP + H2O
-
 Homo sapiens aflatoxin B1/out + ADP + phosphate
-
 ?
cysteinyl leukotriene C4/in + ATP + H2O
-
 Homo sapiens cysteinyl leukotriene C4/out + ADP + phosphate
-
 ?
estradiol 17-beta-D-glucuronide/in + ATP + H2O
-
 Homo sapiens estradiol 17-beta-D-glucuronide/out + ADP + phosphate
-
 ?
additional information
-
 Mus musculus ?
-
 ?
additional information the physiological function can range from a protective role in chemical toxicity and oxidative stress to mediation of inflammatory responses involving cysteinyl leukotrienes Homo sapiens ?
-
 ?
vincristine/in + ATP + H2O
-
 Mus musculus vincristine/out + ADP + phosphate
-
 ?
vincristine/in + ATP + H2O requires cotransport of GSH Homo sapiens vincristine/out + ADP + phosphate
-
 ?

Subunits

Subunits Comment Organism
? 1 * 190000, MRP from lung cancer cell line, calculation from nucleotide sequence Homo sapiens