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Literature summary for 7.6.2.2 extracted from

  • Li-Blatter, X.; Nervi, P.; Seelig, A.
    Detergents as intrinsic P-glycoprotein substrates and inhibitors (2009), Biochim. Biophys. Acta, 1788, 2335-2344.
    View publication on PubMed
Search for more literature for 7.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
cyclosporin A uncompetitive inhibition of the detergentinduced activity Mus musculus
dodecyloctaglycol uncompetitive inhibition of verapamil-induced Pgp ATPase activity Mus musculus
Triton X-100 uncompetitive inhibition of verapamil-induced Pgp ATPase activity Mus musculus
Tween 80 uncompetitive inhibition of verapamil-induced Pgp ATPase activity Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic fibroblast inside-out plasma membrane vesicles of MDR1-transfected mouse embryo fibroblasts (NIH-MDR1-G185) Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + dodecyloctaglycol/in
-
 Mus musculus ADP + phosphate + dodecyloctaglycol/out
-
 ?
ATP + H2O + Triton X-100/in
-
 Mus musculus ADP + phosphate + Triton X-100/out
-
 ?
ATP + H2O + Tween 80/in
-
 Mus musculus ADP + phosphate + Tween 80/out
-
 ?
ATP + H2O + verapamil/in
-
 Mus musculus ADP + phosphate + verapamil/out
-
 ?

Synonyms

Synonyms Comment Organism
P-glycoprotein
-
 Mus musculus