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Literature summary for 7.6.2.2 extracted from
- Vitamin E TPGS P-glycoprotein inhibition mechanism: influence on conformational flexibility, intracellular ATP levels, and role of time and site of access (2010), Mol. Pharm., 7, 642-651.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | CACO-2 cell monolayer experiments preincubated with the nonionic surfactant TPGS 1000 (D-alpha-tocopheryl polyethylene glycol 1000 succinate), produce stronger substrate inhibitory activity than those conducted by direct substrate and surfactant coapplication. TPGS 1000 does not function as a competitive inhibitor in P-gp substrate efflux transport | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Caco-2 cell | - |
Homo sapiens | - |
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Release 2023.1 (January 2023)
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