EC Number   |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
|---|
   7.6.2.2 | 0.000000001 |
- |
cyclosporin A |
inhibits daunorubicin transport, IC50: 0.001 nM |
658514 |
| 7.6.2.2 | 0.000000004 |
- |
verapamil |
inhibits daunorubicin transport, IC50: 0.004 nM |
658514 |
| 7.6.2.2 | 0.000000011 |
- |
loratadine |
inhibits daunorubicin transport, IC50: 0.011 nM, much less inhibitory than cyclosporin A or verapamil, 43% of the inhibition caused by vanadate |
658514 |
| 7.6.2.2 | 0.000000043 |
- |
desloratadine |
weakly inhibits daunorubicin transport, 19% of the inhibition caused by vanadate, IC50: 0.043 nM, desloratadine is no significant inhibitor of P-gp and should not cause clinical drug interactions with agents that are P-gp substrates |
658514 |
| 7.6.2.2 | 0.00019 |
- |
Kol43 |
at 37°C, pH not specified in the publication |
747643 |
| 7.6.2.2 | 0.00025 |
- |
(1Z,4E)-1,5-bis[3,5-bis(methoxymethoxy)phenyl]-2-chloropenta-1,4-dien-3-one |
at 37°C, pH not specified in the publication |
747643 |
| 7.6.2.2 | 0.0003 |
- |
bis[(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-yl] decanedioate |
22°C, pH 7.4, inhibition of verapamil efflux in MCF-7/DX1 (breast adenocarcinoma) cells that over-express P-gp |
711073 |
| 7.6.2.2 | 0.00031 |
- |
(1E,4E)-1-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)penta-1,4-dien-3-one |
at 37°C, pH not specified in the publication |
747643 |
| 7.6.2.2 | 0.00037 |
- |
(1Z,4E)-5-[3,5-bis(methoxymethoxy)phenyl]-2-bromo-1-[2-bromo-3,5-bis(methoxymethoxy)phenyl]penta-1,4-dien-3-one |
at 37°C, pH not specified in the publication |
747643 |
| 7.6.2.2 | 0.0004 |
- |
D-alpha-tocopheryl polyethylene glycol 1000 succinate |
37°C, presence of nicardipine |
689065 |
