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Literature summary for 7.6.2.2 extracted from
- Quantification and characterization of P-glycoprotein-substrate interactions (2006), Biochemistry, 45, 3020-3032.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | binding of drugs to Pgp is not compatible with a classical key-lock or one-pharmacophore model but can be well explained with a modular binding concept, where the energetically most relevant binding module seems to consist of two hydrogen bond acceptor groups | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | binding of drugs to Pgp is not compatible with a classical key-lock or one-pharmacophore model but can be well explained with a modular binding concept, where the energetically most relevant binding module seems to consist of two hydrogen bond acceptor groups | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ABCB1 | - |
Homo sapiens |
| MDR1 | - |
Homo sapiens |
| P-glycoprotein-ATPase | - |
Homo sapiens |
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