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Literature summary for 7.6.2.2 extracted from

  • Lee, Y.M.; Cui, Y.; Koenig, J.; Risch, A.; Jaeger, B.; Drings, P.; Bartsch, H.; Keppler, D.; Nies, A.T.
    Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3) (2004), Pharmacogenetics, 14, 213-223.
    View publication on PubMed
Search for more literature for 7.6.2.2

Cloned(Commentary)

Cloned (Comment) Organism
stable transfected into MDCKII cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
R1297H the naturally occuring mutant protein MRP3-Arg1297His is correctly localized to the basolateral membrane and shows no significant differences in the transport of several organic anions compared to MRP3. Based on the membrane vesicle transport assays, individuals with the MRP3-Arg 1297 His variant are not expected to be affected in their ability to export MRP3 substrates into blood Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.016
-
 17beta-glucuronosyl [6,7-3H]oestradiol vesicles from MRP3-Arg1297His transfected cells Homo sapiens
0.0242
-
 17beta-glucuronosyl [6,7-3H]oestradiol vesicles from MRP3 cells Homo sapiens
0.0346
-
 [1,2,6,7-3H(N)]dehydroepiandrosterone-3-sulfate/in vesicles from MRP3-Arg1297His transfected cells Homo sapiens
0.0463
-
 [1,2,6,7-3H(N)]dehydroepiandrosterone-3-sulfate/in vesicles from MRP3 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + 17beta-glucuronosyl oestradiol/in
-
 Homo sapiens ADP + phosphate + 17beta-glucuronosyl oestradiol/out
-
 ?
ATP + H2O + dehydroepiandrosterone-3-sulfate/in
-
 Homo sapiens ADP + phosphate + dehydroepiandrosterone-3-sulfate/out
-
 ?
ATP + H2O + leukotriene C4/in
-
 Homo sapiens ADP + phosphate + leukotriene C4/out
-
 ?
ATP + H2O + monoglucuronosyl bilirubin/in
-
 Homo sapiens ADP + phosphate + monoglucuronosyl bilirubin/out
-
 ?
ATP + H2O + [1,2,6,7-3H(N)]dehydroepiandrosterone-3-sulfate/in
-
 Homo sapiens ADP + phosphate + [1,2,6,7-3H(N)]dehydroepiandrosterone-3-sulfate/out
-
 ?

Synonyms

Synonyms Comment Organism
MRP3/ABCC3
-
 Homo sapiens
multidrug resistance protein 3
-
 Homo sapiens