Literature summary for 7.6.2.2 extracted from

Arias, A.; Villanueva, S.S.; Ruiz, M.L.; Luquita, M.G.; Veggi, L.M.; Pellegrino, J.M.; Vore, M.; Catania, V.A.; Mottino, A.D.
Regulation of expression and activity of rat intestinal multidrug resistance-associated protein 2 by cholestatic estrogens (2009), Drug Metab. Dispos., 37, 1277-1285.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	spironolactone induced Mdr2 expression	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
gene Mdr2, quantitative expression analysis in the intestine, overview	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
estradiol 17beta-D-glucuronide	competitive inhibition of the transport activity of Mdr2	Rattus norvegicus
additional information	ethynylestradiol selectively diminishes the expression of Mdr2 in the intestine, no inhibition of expression of breast cancer resistance protein, of Mrp3, and expression of multidrug resistance protein 1 is only minimally impaired	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Rattus norvegicus	16020	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + xenobiotic/in	Rattus norvegicus	-	ADP + phosphate + xenobiotic/out	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	adult male Wistar rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
enterocyte	localization at the apical membrane of the enterocyte	Rattus norvegicus	-
intestine	intestinal sacs	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + S-2,4-dinitrophenylglutathione/in	-	Rattus norvegicus	ADP + phosphate + S-2,4-dinitrophenylglutathione/out	-	?
ATP + H2O + xenobiotic/in	-	Rattus norvegicus	ADP + phosphate + xenobiotic/out	-	?

Synonyms

Synonyms	Comment	Organism
ABCC2	-	Rattus norvegicus
breast cancer resistance protein	-	Rattus norvegicus
MRP2	-	Rattus norvegicus
MRP3	-	Rattus norvegicus
multidrug resistance protein 1	-	Rattus norvegicus
multidrug resistance-associated protein 2	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus

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Release 2023.1 (January 2023)