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Literature summary for 7.6.2.2 extracted from

  • Fong, W.F.; Wan, C.K.; Zhu, G.Y.; Chattopadhyay, A.; Dey, S.; Zhao, Z.; Shen, X.L.
    Schisandrol A from Schisandra chinensis reverses P-glycoprotein-mediated multidrug resistance by affecting Pgp-substrate complexes (2007), Planta Med., 73, 212-220.
    View publication on PubMed
Search for more literature for 7.6.2.2

Activating Compound

Activating Compound Comment Organism Structure
schisandrol A isolated from fruit of Schisandra chinensis. Increases cellular retention of P-glycoprotein substrates such as rhodamine 123. Schisandrol A stimulates basal P-glycoprotein ATPase activity, is not competitive to verapamil or progesterone and decreases their Km value without changing Vmax values Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00198
-
 verapamil/in presence of 0.4 mM schisandrol A, pH 7.4, 37°C Homo sapiens
0.00377
-
 progesterone/in presence of 0.4 mM schisandrol A, pH 7.4, 37°C Homo sapiens
0.00397
-
 verapamil/in presence of 0.04 mM schisandrol A, pH 7.4, 37°C Homo sapiens
0.0048
-
 progesterone/in presence of 0.04 mM schisandrol A, pH 7.4, 37°C Homo sapiens
0.00579
-
 verapamil/in pH 7.4, 37°C Homo sapiens
0.0207
-
 progesterone/in pH 7.4, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + progesterone/in
-
 Homo sapiens ADP + phosphate + progesterone/out
-
 ?
ATP + H2O + verapamil/in
-
 Homo sapiens ADP + phosphate + verapamil/out
-
 ?